Long-term follow-up of patients receiving CAR-T cell therapy
Long-term Follow-up Study of Patients Receiving CAR-T Cells
This study is tracking patients who have received CAR-T cell therapy for up to 15 years to see how well the treatment works over time and if there are any long-term health issues.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Medical College of Wisconsin Academic / other |
| Drugs / interventions | CAR-T, Pirtobrutinib, CAR T |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Trial ID | NCT03375619 on ClinicalTrials.gov |
What this trial studies
This study is designed to monitor patients who have received CAR-T cell therapy as part of various clinical trials at the Medical College of Wisconsin and Froedtert Hospital. Participants will be followed for a duration of 2 to 15 years to assess the persistence of CAR-T cells, the occurrence of secondary malignancies, and any other medical complications that may arise. The observational nature of the study allows for comprehensive data collection on long-term outcomes and safety profiles of CAR-T cell treatments.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who have previously enrolled in a CAR-T cell therapy clinical trial at Froedtert Hospital and the Medical College of Wisconsin.
Not a fit: Patients who have not participated in any CAR-T cell therapy trials at the specified institutions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the long-term effects and safety of CAR-T cell therapy for patients with certain types of blood cancers.
How similar studies have performed: Other studies have shown promising results in the long-term follow-up of CAR-T cell therapy, indicating that this approach is both relevant and necessary for understanding patient outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All participants who enrolled in a CAR-T study at Froedtert Hospital \& the Medical College of Wisconsin. Exclusion Criteria: * There are no exclusion criteria for this study.
Where this trial is running
Milwaukee, Wisconsin
- Froedtert Hospital & Medical College of Wisconsin — Milwaukee, Wisconsin, United States (Recruiting)
Study contacts
- Principal investigator: Nirav Shah — Medical College of Wisconsin
- Study coordinator: Medical College of Wisconsin Clinical Cancer Center
- Email: cccto@mcw.edu
- Phone: 414-805-8900
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.