Condition

Alcohol Misuse clinical trials and research

• 10Clinical trials
• 29NIH research projects
• 1New in 30 days
• 4Countries

Newest Alcohol Misuse clinical trials

All recruiting trials (10)

• PSP Alcohol Reset Course for Public Safety Personnel

  A self-guided online program tests whether a digital cognitive-behavioral course can help public safety personnel reduce risky drinking and improve well-being.

  Recruiting University of Regina · Regina, Saskatchewan · NCT07873684

• Digital AI coaching and weekly texts to cut risky drinking in the ED

  A digital AI counseling tool plus weekly SMS reminders aims to help adults with alcohol misuse seen in the emergency department see if their drinking can be reduced.

  Recruiting Stanford University · Palo Alto, California · NCT07661563

• Does a CDT level at ICU admission predict short-term outcomes in critically ill adults?

  This study tests whether high carbohydrate-deficient transferrin levels at ICU admission can predict worse short-term outcomes for adults with critical illness from emergency department admissions.

  Recruiting Medical University of Vienna · Vienna · NCT07632716

• PEth-boosted brief intervention for alcohol use in people with HIV

  In this study, people with HIV who drink at risky levels are randomized to receive standard MOH counseling with or without a PEth blood test result to see if linking test results to counseling helps reduce drinking.

  Recruiting University of California, San Francisco · Mbarara · NCT07444359

• MiREA-AC smartphone program to reduce heavy drinking and cannabis use in college students

  This project will test whether the MiREA-AC smartphone app can help college students cut down on heavy drinking and cannabis use.

  Recruiting at 2 sites mHealth Systems Inc. · Charlotte, North Carolina and 1 other locations · NCT07339150

• Apremilast for reducing alcohol craving in adults with alcohol use disorder

  This study will try two daily doses of apremilast versus placebo to see if they reduce alcohol craving in adults with moderate to severe alcohol use disorder.

  Recruiting at 3 sites Phase 2 National Institute on Alcohol Abuse and Alcoholism (NIAAA) · Los Angeles, California and 2 other locations · NCT07325266

• Adaptive actions during online cognitive behavioural therapy for alcohol misuse

  This project will see if doing helpful daily actions more often is linked to reduced drinking in adults in Canada taking an online cognitive behavioural therapy course for alcohol misuse.

  Recruiting University of Regina · Regina, Saskatchewan · NCT07021053

• Smartphone intervention to reduce alcohol use among homeless adults

  This study is testing whether a smartphone app can help homeless adults reduce their alcohol use more effectively than standard treatment at shelters.

  Recruiting Phase 2/3 University of Oklahoma · Oklahoma City, Oklahoma · NCT06821295

• THRiVE: a peer-led program to support newly separated veterans during the military-to-civilian transition

  This pilot will test whether a peer-led group program based on Behavioral Activation helps newly separated U.S. veterans improve mental health and reduce suicide risk during the transition to civilian life.

  Recruiting RTI International · Durham, North Carolina · NCT06778278

• Online support group to help young Black women reduce alcohol use and increase PrEP uptake

  This study is testing whether an online support group can help young Black women cut down on drinking and use PrEP to prevent HIV.

  Recruiting RTI International · Durham, North Carolina · NCT05753683

NIH-funded research (29)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• GODDESS: Online support for young Black women to reduce alcohol use and boost PrEP in NC

  A virtual group program helps young African American women at risk for HIV reduce alcohol use, address sexual risk, and increase PrEP use in North Carolina.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11402256

• Alcohol, Gut Health, and PrEP: How a brief intervention might help HIV prevention care

  A program to help people using PrEP reduce risky drinking and improve gut health so they can stay on PrEP.

  NIH research University of Louisville · Louisville, United States · NIH-11396995

• How social settings affect alcohol use and risk in young adults

  This grant studies how drinking with others changes how alcohol affects people, with the goal of reducing risky drinking in young adults.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11394392

• Genes, neighborhoods, and alcohol misuse from adolescence to mid-adulthood

  A long-term study using genetic data and neighborhood information to understand how where you live and your genetics influence alcohol use from adolescence into adulthood.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11375116

• Ecological Momentary Intervention to Reduce Alcohol Misuse in Young Women Reproductive Age

  A study will test a real-time intervention using location and moment-based prompts to help young women who drink reduce alcohol use and risky sexual behavior.

  NIH research Yale University · New Haven, United States · NIH-11356518

• How threat-sensitive brain circuits relate to anxiety-driven drinking in adults

  Researchers will use brain scans and smartphone monitoring to learn how anxiety from uncertain threats may lead adults 21 and older to drink more.

  NIH research Univ of Maryland, College Park · College Park, United States · NIH-11332591

• Monthly mood and emotion regulation changes linked to alcohol misuse in premenopausal women

  This project looks at whether monthly mood swings and changes in heart-rate patterns make premenopausal women more likely to misuse alcohol.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11327304

• Understanding how genes and neighborhoods influence alcohol use from teenage years to middle age

  This project looks at how a person's genes and their neighborhood might work together to affect alcohol use and misuse as they grow from teenagers into adults.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11192312

• How being with friends changes alcohol's effects in young adults

  This project looks at how drinking alone versus with a friend changes how alcohol makes young adults feel and whether that relates to risky drinking.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11182664

• Exploring how childhood experiences affect alcohol use in Latino teens

  This study is looking at how tough experiences in childhood might lead to drinking problems in Latino teens, and it wants to find out what helps or hurts this connection, so we can create better support for those who need it.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11163129

• Helping people on PrEP reduce alcohol harms and protect gut health

  This project offers a brief alcohol help program (SBIRT) to people taking PrEP to reduce heavy drinking, protect gut bacteria, and help them keep using their HIV prevention medication.

  NIH research University of Louisville · Louisville, United States · NIH-11143913

• Virtual peer-support app to help young Black women reduce alcohol-related sexual risk and increase PrEP use in North Carolina

  This project uses a mobile app with virtual group sessions to help young Black women in North Carolina cut back on alcohol-related risky sex and increase use of HIV prevention (PrEP).

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11115880

• Understanding how stress and social support affect alcohol misuse in women

  This study looks at how stress and support from friends and family affect alcohol use in pregnant women, aiming to understand what might lead some to drink during pregnancy and how to help them avoid it for the sake of their baby's health.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11098547

• The impact of alcohol misuse on lung infections like pneumonia

  This study looks at how drinking too much alcohol can impact the risk and seriousness of pneumonia in people who already have lung problems, with the goal of finding better ways to care for those patients.

  NIH research Omaha VA Medical Center · Omaha, United States · NIH-11098451

• Understanding how emotional regulation affects alcohol use in women

  This study is looking at how changes in emotions during certain times of the month might affect drinking habits in women who haven't gone through menopause yet, and it hopes to find ways to help prevent alcohol misuse by understanding these connections better.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11053630

• Understanding how anxiety affects alcohol misuse through brain imaging and smartphone assessments

  This study is looking at how anxiety might lead some people to drink more alcohol, using brain scans and smartphone check-ins to see how their brains react to anxiety and uncertainty, and it's for anyone who wants to understand the link between their anxiety and drinking habits better.

  NIH research Univ of Maryland, College Park · College Park, United States · NIH-11044057

• Exploring how social interactions influence alcohol use in young adults

  This study looks at how being around friends or others while drinking can change how young adults feel and behave with alcohol, helping us understand why some might struggle with drinking too much.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10980338

• Exploring how relationship conflicts affect drinking habits in young adults

  This study is looking at how arguments in romantic relationships might affect drinking habits in young adults, and it involves some fun tasks to see how people react while drinking alcohol.

  NIH research New York University · New York, United States · NIH-10928249

• How alcohol use affects HIV prevention medication adherence and gut health.

  This study is looking at how drinking alcohol might affect how well PrEP works for preventing HIV and how it can cause side effects that make it harder for people to stick to their medication, and it’s for individuals at risk for HIV who want to understand the best ways to manage their alcohol use while taking PrEP.

  NIH research University of Louisville · Louisville, United States · NIH-10912467

• Understanding how ADHD affects alcohol use as people age

  This study is looking at how having ADHD as a child might affect drinking habits and problems with alcohol as people reach their 30s, and it’s for anyone who wants to understand how ADHD can influence these issues over time.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10907527

• Understanding and improving treatment for adolescent alcohol misuse

  This study is all about finding better ways to help young people who are having trouble with alcohol by using new tools and methods, and it’s designed for those who want to learn how to make a difference in this area.

  NIH research Brown University · Providence, United States · NIH-10894251

• Creating a virtual tool to help ICU survivors with alcohol misuse access treatment

  This study is creating a helpful online tool for people who have survived an ICU stay and are dealing with alcohol misuse, aiming to inspire them to explore treatment options in a friendly and supportive way.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10889954

• Using a virtual group app to support young African American women in reducing alcohol misuse and improving HIV prevention.

  This study is inviting young African American women in North Carolina to join a friendly online group where they can talk about drinking habits and staying safe from HIV, while also getting support and tips from peers to help them make healthier choices.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-10877060

• N-acetylserotonin helps reduce alcohol misuse after brain injuries.

  This study is looking at how a substance called N-acetylserotonin (NAS) might help people who have had a traumatic brain injury and are dealing with alcohol use problems, by exploring how it could reduce their alcohol cravings and improve their recovery.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10834197

• How alcohol misuse affects recovery from COVID-19 symptoms

  This study is looking at how drinking too much alcohol might make lingering COVID-19 symptoms worse and could lead to more health problems, and it's for people who have had COVID-19 and want to understand how their drinking habits might affect their recovery.

  NIH research Rush University Medical Center · Chicago, United States · NIH-10690068

• How stress and alcohol misuse affect health after COVID-19

  This study is looking at how stress from the pandemic and drinking too much alcohol can affect your health, especially for those who might be more vulnerable, and it aims to understand how these issues can impact your memory and decision-making.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-10686865

• How alcohol misuse affects cognitive and respiratory health in COVID-19 patients

  This study is looking at how drinking too much alcohol might affect people with severe COVID-19 breathing problems, especially those on breathing machines, to see if it makes their thinking and breathing worse, and to find ways to help them recover better.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10671588

• Understanding how community challenges affect alcohol use in Appalachian teens

  This study is looking at how tough situations in rural West Virginia affect teens' drinking habits and how things like community support and caffeine might help them make better choices about alcohol.

  NIH research West Virginia University · Morgantown, United States · NIH-10662291

• Creating a personalized feedback tool to help young adults reduce alcohol use

  This study is creating a friendly online tool to help young adults see how their drinking habits affect their money and time, so they can make healthier choices that fit their personal goals.

  NIH research University of Washington · Seattle, United States · NIH-10523858

Related topics

Quick answers

How many Alcohol Misuse clinical trials are recruiting right now?

10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (6 trials), Canada (2 trials), Austria (1 trial), Uganda (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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