How alcohol use affects HIV prevention medication adherence and gut health.
Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention
This study is looking at how drinking alcohol might affect how well PrEP works for preventing HIV and how it can cause side effects that make it harder for people to stick to their medication, and it’s for individuals at risk for HIV who want to understand the best ways to manage their alcohol use while taking PrEP.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-10912467 on NIH RePORTER |
What this research studies
This research investigates the relationship between alcohol consumption and the effectiveness of pre-exposure prophylaxis (PrEP) in preventing HIV. It aims to understand how alcohol use may worsen side effects of PrEP, particularly gastrointestinal issues, and how these effects can impact adherence to the medication. The study will explore decision-making processes regarding alcohol and PrEP use among individuals at risk for HIV, and it will evaluate the effectiveness of a specific intervention (SBIRT) designed to reduce hazardous alcohol use and improve PrEP adherence. Participants will be followed over time to assess changes in their alcohol use, gut health, and adherence to PrEP.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-negative individuals who are at risk for HIV and currently using or considering PrEP while also consuming alcohol.
Not a fit: Patients who do not consume alcohol or are not at risk for HIV may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for maintaining PrEP adherence among individuals who consume alcohol, ultimately enhancing HIV prevention efforts.
How similar studies have performed: While there is limited research specifically addressing the interaction between alcohol use and PrEP adherence, similar interventions have shown promise in improving substance use outcomes in other populations.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Barve, Shirish S — University of Louisville
- Study coordinator: Barve, Shirish S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.