Condition

Advanced Soft Tissue Sarcoma clinical trials and research

• 10Clinical trials
• 5Countries

Newest Advanced Soft Tissue Sarcoma clinical trials

All recruiting trials (10)

• Lifileucel (Tumor-infiltrating lymphocytes) for advanced soft tissue sarcoma

  This study tests lifileucel, a cell therapy made from a patient’s own tumor cells, in adults with unresectable or metastatic soft tissue sarcoma who have had prior treatments to see if it helps shrink tumors and improve outcomes.

  Recruiting at 2 sites Phase 2 Iovance Biotherapeutics, Inc. · Tampa, Florida and 1 other locations · NCT07741877

• Maintenance pegylated liposomal doxorubicin versus observation for advanced soft tissue sarcoma after anthracycline control (MELODY)

  This trial tests whether giving maintenance pegylated liposomal doxorubicin (PLD) every 4 weeks helps people with advanced soft tissue sarcoma whose disease was controlled after first-line anthracycline chemotherapy, compared with active surveillance.

  Recruiting at 7 sites Phase 2 National Health Research Institutes, Taiwan · Kaohsiung City and 6 other locations · NCT06981637

• Adding abemaciclib to gemcitabine chemotherapy for advanced soft tissue sarcoma

  This phase 1/2 trial tests whether adding the targeted drug abemaciclib to gemcitabine is safe and works better than gemcitabine plus docetaxel for adults with advanced or metastatic leiomyosarcoma or dedifferentiated liposarcoma whose tumors are Rb-positive.

  Recruiting Phase 1/2 National Cancer Institute (NCI) · Houston, Texas · NCT06498648

• Cadonilimab plus Adriamycin for advanced soft tissue sarcoma

  This study will try cadonilimab combined with adriamycin as first-line treatment for adults under 60 with advanced soft tissue sarcoma.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06367075

• Using imaging technology to evaluate treatments for advanced soft tissue sarcoma

  This study is testing a new way to use imaging technology to see if combining immunotherapy and targeted therapy can help people with advanced soft tissue sarcoma and predict their outcomes.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06062927

• Treatment for advanced soft tissue sarcoma using NY-ESO-1 TCR-T cells

  This study is testing a new treatment using specially designed immune cells to see if it can help people with advanced soft tissue sarcoma who haven't had success with other treatments.

  Recruiting Shenzhen University General Hospital · Shenzhen, Guangdong · NCT05620693

• Combining Atezolizumab and Selinexor for Alveolar Soft Part Sarcoma

  This study is testing if a combination of two drugs, atezolizumab and selinexor, can help shrink tumors in patients with advanced alveolar soft part sarcoma better than standard treatments.

  Recruiting at 12 sites Phase 2 National Cancer Institute (NCI) · Los Angeles, California and 12 other locations · NCT05333458

• Combining pembrolizumab and cabozantinib for advanced sarcomas

  This study is testing if combining two treatments, pembrolizumab and cabozantinib, can help people with advanced types of sarcoma feel better and improve their condition.

  Recruiting at 6 sites Phase 2 Institut Bergonié · Bordeaux and 9 other locations · NCT05182164

• Testing PM14 for advanced soft tissue sarcomas and other solid tumors

  This study is testing a new treatment called PM14 for people with advanced soft tissue sarcomas and other solid tumors to see if it can help them live longer and feel better.

  Recruiting at 4 sites Phase 1/2 Grupo Espanol de Investigacion en Sarcomas · Zaragoza, Aragon and 3 other locations · NCT05146440

• Combination treatment for advanced soft tissue sarcoma

  This study is testing a new combination of treatments using Trabectedin, Ipilimumab, and Nivolumab to see if it can help people with advanced soft tissue sarcoma who have already received other treatments.

  Recruiting Phase 1/2 Sarcoma Oncology Research Center, LLC · Santa Monica, California · NCT03138161

Related topics

Quick answers

How many Advanced Soft Tissue Sarcoma clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (4 trials), China (3 trials), Spain (1 trial), Taiwan (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1/2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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