Physiology-guided Epinephrine Dosing in Pediatric Cardiac Arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, multicenter cohort study will examine the physiologic responses to epinephrine during pediatric in-hospital cardiac arrest and explore dosing strategies based on initial responses. The team will use collected data to identify outcome-discriminating physiologic markers and to develop machine learning tools to guide intra-arrest therapy. Eligible participants are children in intensive care units who receive chest compressions for at least one minute, with several exclusions to avoid cases with poor prognosis or non-survivable conditions. The study is led by the Children’s Hospital of Philadelphia with NHLBI collaboration and includes sites in California, Colorado, and Utah. The aim is to improve decision-making for epinephrine administration during pediatric resuscitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Arrest in an ICU
* Patients received chest compressions for at least 1 minute

Exclusion Criteria:

* Lack of commitment to aggressive therapies (e.g., CPR performed as part of end-of-life care)
* Brain death determination prior to CPR
* Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes)
* Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR

Where it's running

• Choc
  Orange, California, United States Recruiting
• Stanford Medicine Children's Health
  Stanford, California, United States Recruiting
• Children's Hospital Colorado
  Denver, Colorado, United States Recruiting
• Nemours Children's Health
  Wilmington, Delaware, United States Recruiting
• Children's Healthcare of Atlanta
  Atlanta, Georgia, United States Recruiting
• Comer Children's Hospital
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Ryan Morgan, MD, MTR — Children's Hospital of Philadelphia
• Study coordinator: Jessica Goldstein
• Email: goldsteij1@chop.edu
• Phone: 215-590-1859

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.