Using Positive End-Expiratory Pressure during CPR for Cardiac Arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates whether applying Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) can improve outcomes for adults experiencing out-of-hospital cardiac arrest. Participants will be randomly assigned to receive either CPR with PEEP set at 5 cm of water pressure or standard CPR without PEEP. The study aims to evaluate the effectiveness of PEEP in enhancing oxygenation, increasing the rate of Return of Spontaneous Circulation (ROSC), and improving survival rates with favorable neurological outcomes. The trial will be conducted in Belgium, involving emergency medical teams trained in advanced life support.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age: Adults aged 18 years and older.
2. Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest.
3. CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team.
4. Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts.

Exclusion Criteria:

1. Cardiac arrest in patient younger than 18 years of age.
2. Traumatic cardiac arrest, including drowning, penetrating or blunt injury, and burns.
3. Immediate Return of Spontaneous Circulation (ROSC): Patients who achieve ROSC before intubation and initiation of intubation.
4. Pregnancy.
5. Mechanical ventilation during arrest: patients already receiving mechanical ventilation at the moment of cardiac arrest, due to reasons other than their arrest, will be excluded.
6. Do Not Resuscitate (DNR) Orders: Patients with existing DNR orders or any advanced directive indicating that CPR should not be performed.
7. Failure to intubate: if intubation is unsuccessful, ventilation by any means (MBV, SGA) should take priority over the study protocol, and the patient is excluded.
8. Enrolment in Other Studies: Patients currently enrolled in another interventional clinical trial that could interfere with the outcomes of this study.

Where it's running

• AZ Oostende
  Ostend, West-Flandres, Belgium Recruiting
• AZORG: campus Merestraat
  Aalst, Belgium Recruiting
• AZORG: Campus Moorselbaan
  Aalst, Belgium Recruiting
• AZORG: campus Geraardsbergen
  Geraardsbergen, Belgium Recruiting
• UZ Ghent
  Ghent, Belgium Recruiting
• AZ Zeno
  Knokke, Belgium Recruiting

Study contacts

• Principal investigator: Saïd Hachimi Idrissi, MD, PhD, Professor — UZ Gent
• Study coordinator: Thomas Tackaert, MD
• Email: thomas.tackaert@ugent.be
• Phone: 0032 53 72 49 96

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Hyperacute Neurobiomarker Kinetics in Acute Brain Injury: What Happens in Minutes After Injury

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.