Risk of malignant arrhythmias after acute coronary syndrome
Official title: Current Relevance of Malignant Cardiac Arrhythmia in Patients Admitted for Acute Coronary Syndrome
Run by Catharina Ziekenhuis Eindhoven · NCT07824050 · Data updated 2026-11-12
This study tracks how often dangerous heart rhythms occur in adults admitted for ACS and looks for patterns that might predict them.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2775 (estimated) |
| Sponsor | Catharina Ziekenhuis Eindhoven Academic / other |
| Locations | 1 site (Eindhoven, North Brabant) |
| Status | Recruiting |
| Started | July 14, 2026 |
| Main results expected | April 1, 2029 |
| Study ends | April 1, 2029 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT07824050 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older admitted with ACS (STEMI, NSTEMI, unstable angina) or out-of-hospital cardiac arrest due to ACS, admitted to relevant hospital units.
✕Probably not a fit
Patients without malignant arrhythmias or those not at risk for such events may not benefit from this observational analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study analyzes the incidence of malignant arrhythmias, specifically sustained VT and VF, in adults admitted with acute coronary syndromes. It aims to identify timing and predictors of these events during initial hospitalization across STEMI, NSTEMI, and unstable angina. Secondary questions examine the distribution of arrhythmias, differences between polymorphic and monomorphic VT, associated in-hospital mortality, and the occurrence of asystole/PEA. The research uses existing hospital data from ICSU units to characterize risk and inform monitoring practices. Interventions are not being tested; the study observes real-world care as it occurs.
Why it matters
Potential benefit: Findings could improve risk stratification and monitoring decisions for ACS patients, potentially reducing arrhythmia-related complications and deaths.
How similar studies have gone: Previous observational work in ACS has shown that certain factors predict arrhythmic risk, supporting the value of this approach but the exact risk patterns may vary by center.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria Patients * Aged 18 years or older * With acute coronary syndrome (ST-elevation myocardial infarction, non-ST-elevation myocardial infarction, and unstable angina pectoris) or out-of-hospital cardiac arrest (OHCA) due to ACS * Admitted to the emergency cardiac care unit, emergency department, coronary care unit (CCU), intensive care unit (ICU), or cardiology ward. Exclusion criteria \- Patients who have indicated that their data may not be used for scientific research or for improving the quality of care.
Where it's running
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Catharina Hospital Eindhoven
Eindhoven, North Brabant, Netherlands Recruiting
Study contacts
- Principal investigator: Luuk C Otterspoor, Dr. M.D. — Catharina Ziekenhuis Eindhoven
- Study coordinator: Maud E Kortman, M.D.
- Email: maud.kortman@catharinaziekenhuis.nl
- Phone: 040 - 239 91 11
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.