Hyperacute Neurobiomarker Kinetics in Acute Brain Injury: What Happens in Minutes After Injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the time-dependent release of neurobiomarkers such as S100B, GFAP, NSE, UCH-L1, NFL, Tau, and related microRNAs and lipids during the hyperacute phase of brain injury. Participants include adults with polytrauma (including TBI), those treated for cardiac arrest in the prehospital setting, and severe TBI patients upon hospital admission, enrolled across multiple Hungarian sites. Blood samples are collected in the prehospital and ED windows to characterize biomarker kinetics and their potential for early prognostic use. The study aims to fill gaps about whether biomarker levels rise immediately or gradually and how quickly they become detectable. This knowledge could inform early decision-making in emergency care and triage.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Age 18 years or older (all arms)
* Polytraumatized patients categorized as T1 triage by the first responder based on injury mechanism and/or sustained injuries, with intubation indicated by the first responder (Arm 1)
* Cardiac arrest treated in the prehospital setting (Arm 2)
* Severe traumatic brain injury enrolled at hospital admission (Arm 3)

Exclusion Criteria (all arms)

* Age under 18 years
* Pre-existing neurological or psychiatric conditions
* Hypothermia or hyperthermia at the time of enrollment
* Pregnancy

Where it's running

• University of Pécs Clinical Center, Department of Emergency Medicine
  Pécs, Branya, Hungary Recruiting
• Petz Aladár University Teaching Hospital, Emergency Department
  Győr, Győr-Moson-Sopron, Hungary Recruiting
• Hungarian National Ambulance Service
  Budapest, Pest County, Hungary Recruiting
• North Pest Central Hospital - Military Hospital, Emergency Centre
  Budapest, Pest County, Hungary Recruiting

Study contacts

• Study coordinator: Endre Czeiter, MD, PhD
• Email: endre.czeiter@gmail.com
• Phone: +36205576026

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.