Using advanced MRI to study brain function in patients with deep brain stimulation
3T MRI in Patients With Deep Brain Stimulation (DBS)
This study is testing how deep brain stimulation affects brain function and structure in people with conditions like Parkinson's and depression by using advanced MRI scans.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT03153670 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of deep brain stimulation (DBS) on brain structure and function using high-resolution MRI techniques. It aims to enroll patients who are undergoing or have undergone DBS for various neurological and psychiatric disorders, including Parkinson's disease and depression. Participants will undergo a series of MRI scans to assess brain changes associated with DBS, both when the stimulation is turned on and off. The goal is to enhance understanding of brain functioning and improve post-operative follow-up for DBS patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 85 who are undergoing or have undergone DBS electrode placement for conditions like Parkinson's disease or epilepsy.
Not a fit: Patients with serious cognitive impairments or those unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and outcomes for patients receiving deep brain stimulation.
How similar studies have performed: Other studies have shown promising results using advanced imaging techniques in conjunction with DBS, suggesting this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 85 years of age * Participants must be planned to undergo, or have undergone implantation of DBS electrodes * Participants must be able to understand the purpose of this research and must sign the informed consent form. * Participants must understand that the role of this research is to enhance our understanding of brain functioning and that he/she will not directly or indirectly benefit from the study. Exclusion Criteria: * Participants who have serious cognitive or psychological impairments and cannot give informed consent. * Participants who are unable to effectively or efficiently communicate, for example patients suffering from speech deficits (dysarthria, aphasia) or are non-English speaking.
Where this trial is running
Toronto, Ontario
- Toronto Western Hospital — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Andres Lozano — University Health Network, Toronto
- Study coordinator: Alexandre Boutet, MD/MSc
- Email: alexandre.boutet@mail.utoronto.ca
- Phone: (647) 463-5513
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.