Using advanced MRI to study brain function in patients with deep brain stimulation
Official title: 3T MRI in Patients With Deep Brain Stimulation (DBS)
Run by University Health Network, Toronto · NCT03153670 · Data updated 2026-11-12
This study is testing how deep brain stimulation affects brain function and structure in people with conditions like Parkinson's and depression by using advanced MRI scans.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | June 1, 2017 |
| Main results expected | December 1, 2028 |
| Study ends | December 1, 2030 |
| Registry record updated | August 13, 2026 |
| Trial ID | NCT03153670 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 85 who are undergoing or have undergone DBS electrode placement for conditions like Parkinson's disease or epilepsy.
✕Probably not a fit
Patients with serious cognitive impairments or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of deep brain stimulation (DBS) on brain structure and function using high-resolution MRI techniques. It aims to enroll patients who are undergoing or have undergone DBS for various neurological and psychiatric disorders, including Parkinson's disease and depression. Participants will undergo a series of MRI scans to assess brain changes associated with DBS, both when the stimulation is turned on and off. The goal is to enhance understanding of brain functioning and improve post-operative follow-up for DBS patients.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and outcomes for patients receiving deep brain stimulation.
How similar studies have gone: Other studies have shown promising results using advanced imaging techniques in conjunction with DBS, suggesting this approach has potential.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 85 years of age * Participants must be planned to undergo, or have undergone implantation of DBS electrodes * Participants must be able to understand the purpose of this research and must sign the informed consent form. * Participants must understand that the role of this research is to enhance our understanding of brain functioning and that he/she will not directly or indirectly benefit from the study. Exclusion Criteria: * Participants who have serious cognitive or psychological impairments and cannot give informed consent. * Participants who are unable to effectively or efficiently communicate, for example patients suffering from speech deficits (dysarthria, aphasia) or are non-English speaking.
Where it's running
-
Toronto Western Hospital
Toronto, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Andres Lozano — University Health Network, Toronto
- Study coordinator: Alexandre Boutet, MD/MSc
- Email: Neurosurgery.Research@uhn.ca
- Phone: 416 603-5800 Ext 3421
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.