Identifying biomarkers for Alzheimer's disease in the Chinese population
Identifying Biomarkers in Alzheimer's Disease
Chinese University of Hong Kong · NCT05655650
This study is trying to find specific signs in blood and brain scans that can help detect Alzheimer's disease earlier in people from the Chinese community.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong (other) |
| Locations | 1 site (Hong Kong, Hong Hong) |
| Trial ID | NCT05655650 on ClinicalTrials.gov |
What this trial studies
This observational cohort study aims to identify biomarkers associated with Alzheimer's disease (AD) in a local Chinese population. Participants will undergo a series of cognitive assessments, blood tests, brain MRI scans, brain PET scans, and retinal imaging at baseline and during six yearly follow-ups. The study hypothesizes that blood-based proteomics, retinal imaging, and advanced imaging techniques can enhance the accuracy of early detection and staging of AD. By focusing on early detection, the study seeks to contribute to the understanding of AD progression and potential interventions.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals of Chinese ethnicity with a clinical diagnosis of probable Alzheimer's disease.
Not a fit: Patients with non-Alzheimer's dementia or contraindications for MRI or PET scans may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection methods for Alzheimer's disease, allowing for timely interventions.
How similar studies have performed: Other studies have shown promise in identifying biomarkers for Alzheimer's disease, but this specific approach focusing on the Chinese population is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Chinese ethnicity * \[For dementia group, clinical diagnosis of "probable Alzheimer's disease" according to recommendation from the National Institute on Aging-Alzheimer's Association workgroups (NIA-AA) Exclusion Criteria: * Clinical diagnosis of non-AD dementia * contraindication for MRI or PET
Where this trial is running
Hong Kong, Hong Hong
- Chinese University of Hong Kong — Hong Kong, Hong Hong, Hong Kong (RECRUITING)
Study contacts
- Study coordinator: Pualine Kwan
- Email: paulinekwan@cuhk.edu.hk
- Phone: +852 26352160
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Neuro-Degenerative Disease, Alzheimer Disease