Exercise ECG to tell hypertensive heart disease from obstructive CAD
Official title: Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging Study
Run by University of Pisa · NCT07847463 · Data updated 2026-11-12
This study tests whether exercise ECG can distinguish heart problems caused by high blood pressure from those caused by obstructive coronary artery disease in patients being evaluated for chest pain.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Pisa Academic / other |
| Locations | 1 site (Pisa, PI) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | September 1, 2028 |
| Study ends | September 1, 2029 |
| Registry record updated | September 29, 2026 |
| Trial ID | NCT07847463 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with suspected CAD who have or may have LVH and no RBBB on ECG.
✕Probably not a fit
Patients without LVH or obstructive CAD, or those with conduction abnormalities like RBBB, may derive limited or no benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this prospective observational study, adults suspected of having coronary artery disease will undergo exercise ECG, echocardiography, stress CMR, and CCTA. Participants will be grouped by the presence or absence of left ventricular hypertrophy and obstructive CAD, with stress CMR serving as the reference for inducible ischemia. The researchers will compare ECG patterns across groups and use multivariable analysis to identify ECG predictors of obstructive CAD and ischemia. The goal is to determine how well exercise ECG can differentiate hypertensive heart disease from CAD-related abnormalities. No interventions are being tested, just diagnostic imaging correlations.
Why it matters
Potential benefit: If successful, exercise ECG could improve noninvasive differentiation between hypertensive heart disease and CAD, potentially guiding further testing and management.
How similar studies have gone: Previous imaging studies have explored multimodality approaches to distinguish CAD from LVH, with varying success; this study builds on those methods in a specific diagnostic context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with CAD and LVH Exclusion Criteria: * Patients with RBBB
Where it's running
-
Azienda Ospedaliero-Universitaria Pisana
Pisa, Pi, Italy Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.