Clinical trial Recruiting at 1 site Observational Ages 18 to 99

Exercise ECG to tell hypertensive heart disease from obstructive CAD

Official title: Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging Study

Run by University of Pisa · NCT07847463 · Data updated 2026-11-12

This study tests whether exercise ECG can distinguish heart problems caused by high blood pressure from those caused by obstructive coronary artery disease in patients being evaluated for chest pain.

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Quick facts

Study typeObservational
Ages18 Years to 99 Years
SexAll
Enrollment30 (estimated)
SponsorUniversity of Pisa
Academic / other
Locations1 site (Pisa, PI)
StatusRecruiting
StartedSeptember 1, 2026
Main results expectedSeptember 1, 2028
Study endsSeptember 1, 2029
Registry record updatedSeptember 29, 2026
Trial IDNCT07847463 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults with suspected CAD who have or may have LVH and no RBBB on ECG.

Probably not a fit

Patients without LVH or obstructive CAD, or those with conduction abnormalities like RBBB, may derive limited or no benefit from this approach.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this prospective observational study, adults suspected of having coronary artery disease will undergo exercise ECG, echocardiography, stress CMR, and CCTA. Participants will be grouped by the presence or absence of left ventricular hypertrophy and obstructive CAD, with stress CMR serving as the reference for inducible ischemia. The researchers will compare ECG patterns across groups and use multivariable analysis to identify ECG predictors of obstructive CAD and ischemia. The goal is to determine how well exercise ECG can differentiate hypertensive heart disease from CAD-related abnormalities. No interventions are being tested, just diagnostic imaging correlations.

Why it matters

Potential benefit: If successful, exercise ECG could improve noninvasive differentiation between hypertensive heart disease and CAD, potentially guiding further testing and management.

How similar studies have gone: Previous imaging studies have explored multimodality approaches to distinguish CAD from LVH, with varying success; this study builds on those methods in a specific diagnostic context.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with CAD and LVH

Exclusion Criteria:

* Patients with RBBB

Where it's running

  • Azienda Ospedaliero-Universitaria Pisana
    Pisa, Pi, Italy
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.