Porous zirconia shell to widen the jawbone before implants
Official title: Histological and Histomorphometric Assessment With Inflammatory Profile Analysis of Bone Tissue After Horizontal Ridge Augmentation of the Lower Posterior Mandible Using a Novel Customized Porous Zirconia Shell Technique: Clinical Case Study
Run by October University for Modern Sciences and Arts · NCT07841158 · Data updated 2026-11-12
A small group of adults with a narrow lower back jaw will try a custom porous zirconia shell placed over bone grafts to see if it helps form good-quality new bone before placing dental implants.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | October University for Modern Sciences and Arts Academic / other |
| Locations | 1 site (Giza, Giza Governorate) |
| Status | Recruiting |
| Started | March 15, 2025 |
| Main results expected | May 1, 2027 |
| Study ends | July 1, 2027 |
| Registry record updated | September 30, 2026 |
| Trial ID | NCT07841158 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 21 with Seibert Class I horizontal defects in the posterior mandible, adequate inter-arch space, good oral hygiene, and motivation for treatment.
✕Probably not a fit
Patients with systemic conditions affecting healing, pregnancy, smoking, or poor oral hygiene may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-arm study tests a digitally designed, 1.5 mm porous zirconia shell fixed over autogenous bone with xenograft in the posterior mandible to widen the ridge. The goal is to analyze histology, histomorphometry, and inflammatory markers in tissue after 6 months and to evaluate the bone’s suitability for implant placement. Participants receive preoperative periodontal therapy, CBCT scans, surgical grafting with shell fixation, and follow-up visits including biopsy collection at implant time. Outcomes will describe bone quality, scaffold integration, and inflammatory response. The study helps determine whether zirconia shells can safely replace autogenous bone plates in this procedure.
Why it matters
Potential benefit: If successful, the approach could provide a less invasive way to rebuild the jawbone for implants with potentially fewer donor-site complications.
How similar studies have gone: This approach is novel in using a customized zirconia shell for ridge augmentation; prior work suggests zirconia is biocompatible and osteoconductive but has not been studied as a shell replacing autogenous bone plates.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age more than 21 years old * Horizontal bone loss in the lower posterior area (Seibert Class I) * Enough inter-arch space for placement of implant-supported prosthesis * Motivated patient to have the treatment * Good oral hygiene Exclusion Criteria: * Patients with systemic conditions that could interfere with the healing process * Pregnant females * Smokers * Poor oral hygiene
Where it's running
-
October University for Modern Sciences and Arts (MSA), Faculty of Dentistry
Giza, Giza Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Mohammed Mahmoud Abed, BDS
- Email: mohammed.mahmoud12@msa.edu.eg
- Phone: 00201118322238
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.