Test of Pro-Adrenomedullin for diagnosing acute appendicitis in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, observational study at a single center enrolling up to 400 adults (18–90) undergoing appendectomy for acute appendicitis and healthy controls. The study measures Pro-Adrenomedullin levels in blood and compares them with standard inflammatory biomarkers (CRP, NLR) and routine diagnostics. It aims to see how well Pro-ADM distinguishes appendicitis from health and whether it predicts complicated disease. Data collected include medical history, clinical findings, imaging, and laboratory tests. Participants provide informed consent and undergo blood sampling for Pro-ADM along with standard labs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults aged 18 to 90 years.
2. Patients presenting to the emergency department within 48 hours of the onset of abdominal pain, either directly or following referral from another healthcare institution with a diagnosis or suspicion of acute appendicitis.
3. Patients undergoing appendectomy for acute appendicitis (acute appendicitis group).
4. Individuals attending outpatient clinics for routine health evaluations without abdominal pain or active inflammatory disease (control group).
5. Provision of informed consent for participation in the study.

Exclusion Criteria:

1. Age younger than 18 years or older than 90 years.
2. Use of antibiotics or systemic corticosteroids within the preceding month.
3. Active malignancy.
4. Immunosuppressive disease or ongoing immunosuppressive treatment.
5. Abdominal surgery within the preceding three months.
6. Heart failure, renal failure, or liver cirrhosis.
7. Pregnancy or postpartum period.
8. Inability to provide informed consent due to psychiatric disorders.

Where it's running

• Bursa Yuksek Ihtisas Training and Research Hospital
  Bursa, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Ugur Duman, MD — University of Health Sciences Turkiye, Bursa Yuksek Ihtisas Training and Research Hospital
• Study coordinator: Ugur Duman, MD
• Email: ugur.duman@sbu.edu.tr
• Phone: +905458177971

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.