Urinary PGE-M to help predict acute appendicitis in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a 12-month observational study enrolling about 100 children aged 5–17 who present with acute abdominal pain and signs suggestive of appendicitis at the University Hospital of Split. Participants will have routine labs and a urine sample collected to measure prostaglandin E urinary metabolite (PGE-M) levels, with clinical course, imaging, surgical findings, and final diagnosis recorded. Investigators will compare PGE-M levels between children with confirmed appendicitis and those with other causes of abdominal pain to see if PGE-M is higher in appendicitis. The study involves minimal additional risk because urine and routine blood samples are collected as part of care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* children of age 5 -17 years with acute abdominal pain
* children with clinical signs of acute appendicitis

Exclusion Criteria:

* previous diagnosis of chronic and/or malignant disease
* children who had previous abdominal surgery
* pregnancy

Where it's running

• University Hospital of Split
  Split, Croatia Recruiting

Study contacts

• Study coordinator: Tomislav Žuvela, Doctor of Medicine, MD
• Email: tomislav.zuvela29@gmail.com
• Phone: +385919008148

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.