Inflammatory biomarkers in blood and appendix tissue in acute appendicitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study recruits adults with suspected acute appendicitis who are scheduled for appendectomy. It measures multiple inflammatory biomarkers in blood and in appendix tissue, and analyzes their relationships with disease severity and standard clinical findings. The goal is to see if tissue and systemic biomarkers together reflect the level of inflammation and can improve severity assessment beyond current methods. The intervention is limited to the surgical procedure (appendectomy) and biomarker analyses on collected specimens. Enrollment is at an Istanbul hospital with defined inclusion and exclusion criteria to ensure reliable data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults aged 18-65 years. Willingness to participate in the study and provision of written informed consent.

Suspected acute appendicitis based on clinical, laboratory, and/or imaging findings.

Scheduled for appendectomy following general surgical evaluation. Availability of an appendectomy specimen suitable for postoperative histopathological examination.

Availability of sufficient clinical and laboratory records for study evaluation.

Exclusion Criteria:

Age younger than 18 years or older than 65 years. Refusal to participate or failure to provide written informed consent. Presence of an active infection that may affect the systemic inflammatory response during the preoperative period.

Concomitant active infectious diseases, including pneumonia, urinary tract infection, or sepsis.

Chronic inflammatory or autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, or systemic lupus erythematosus.

History of malignancy or active malignancy. Chronic renal failure or advanced liver failure. Use of immunosuppressive therapy. Use of corticosteroids, chemotherapy, or biological agents. Preoperative use of antibiotics or anti-inflammatory medications at a level that may significantly affect inflammatory biomarker measurements.

Pregnancy or breastfeeding. Identification of additional intra-abdominal pathology unrelated to appendicitis during appendectomy.

Failure to confirm acute appendicitis on postoperative histopathological examination.

Inadequate biological sample quantity or failure to store biological samples under appropriate conditions.

Where it's running

• Haydarpaşa Numune Training and Research Hospital
  Istanbul, Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Emre B Akçay
• Email: dr.eberatakcay@gmail.com
• Phone: +90 535 711 92 21

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.