Comparing CT scan reports and the AIR score in adults having an appendectomy for suspected appendicitis.
Official title: Prospective Evaluation of the Impact of Computed Tomography Reporting and AIR Scoring System on Negative Appendectomy Rates in Patients With Acute Appendicitis
Run by Sanliurfa Education and Research Hospital · NCT07496723 · Data updated 2026-11-12
This will try to see if CT scan reports and the Appendicitis Inflammatory Response (AIR) score can accurately identify true appendicitis in adults who have an appendectomy after a CT suggests appendicitis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Sanliurfa Education and Research Hospital Government |
| Locations | 1 site (Sanliurfa, Şanlıurfa) |
| Status | Recruiting |
| Started | March 18, 2026 |
| Main results expected | January 31, 2027 |
| Study ends | January 31, 2027 |
| Registry record updated | April 1, 2026 |
| Trial ID | NCT07496723 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 years or older who had a CT reported as compatible with appendicitis and then underwent appendectomy after emergency department evaluation.
✕Probably not a fit
Patients taken directly to surgery without a preoperative CT, children, pregnant patients, or those with other intraoperative pathologies are excluded and will not benefit from this study's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center prospective observational study enrolls adults presenting to the emergency department who receive a CT scan reported as compatible with acute appendicitis and subsequently undergo appendectomy. Clinical and demographic data, routine labs, and AIR score components are collected prospectively, and CT findings are taken from routine radiology reports. Surgeons will grade intraoperative severity using the AAST appendicitis scale and final diagnosis will be based on histopathology. The primary outcome is the negative appendectomy rate, with secondary analyses comparing agreement and diagnostic performance between AIR score, CT reports, intraoperative grading, and pathology across subgroups.
Why it matters
Potential benefit: If successful, this could help reduce unnecessary appendectomies and improve diagnostic confidence by clarifying how CT reports and the AIR score agree with pathology.
How similar studies have gone: Prior research shows CT and clinical scores like the AIR score can lower negative appendectomy rates, but prospective single-center data specifically linking CT reports, AIR score, intraoperative grading, and pathology are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Presentation to the emergency department with suspected acute appendicitis * Underwent computed tomography after clinical evaluation * Computed tomography report compatible with acute appendicitis * Underwent appendectomy for presumed acute appendicitis * Provided informed consent Exclusion Criteria: * Age younger than 18 years * Pregnancy * Planned additional surgical intervention in the same session for a reason other than appendicitis * Intraoperative finding of a non-appendiceal pathology requiring a different surgical procedure * Refusal to participate in the study
Where it's running
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Sanliurfa Education and Research Hospital
Sanliurfa, Şanlıurfa, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Vedat Kaplan, MD
- Email: vedat_kaplan_@hotmail.com
- Phone: +905459045165
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.