See how well the lungs distribute dissolved xenon gas during MRI in HSCT patients and others
Official title: Assessing Pulmonary Changes in Hematopoietic Stem-Cell Transplantation Patients and Patients With Rare-Lung Diseases Using Hyperpolarized Xe MR Lung Imaging
Run by Children's Hospital Medical Center, Cincinnati · NCT07823036 · Data updated 2026-11-12
This study tests a special MRI method using hyperpolarized xenon gas to visualize how gas and dissolved xenon move through the lungs in people who have HSCT, respiratory issues, or are healthy controls.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 3 Years and up |
| Sex | All |
| Enrollment | 550 (estimated) |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Status | Recruiting |
| Started | July 24, 2024 |
| Main results expected | July 2029 |
| Study ends | July 2029 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT07823036 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 3 years and older being evaluated for HSCT, those with respiratory conditions or gas-exchange impairment, and healthy volunteers who can undergo MRI.
✕Probably not a fit
Participants whose condition does not involve gas exchange impairment or who cannot safely undergo MRI may have limited or no direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an open-label, non-randomized study enrolling both children (ages 3–17) and adults (18+) who are being evaluated for HSCT, have respiratory conditions, or are healthy controls. It aims to optimize and test Xe MRI techniques that separately image ventilation, dissolved-phase xenon in lung tissue, and dissolved xenon in red blood cells. Researchers will collect Xe ventilation and regional distribution images and compare them with clinical lung measures to understand day-to-day variability. The study uses hyperpolarized 129Xe as the imaging agent and will monitor safety and tolerability during MRI scans.
Why it matters
Potential benefit: If successful, the imaging approach could improve understanding of lung gas exchange and help tailor monitoring for HSCT patients and others with respiratory issues.
How similar studies have gone: Prior studies using xenon MRI have shown promising insights into lung ventilation and gas exchange, but this specific dissolved-phase and RBC-distribution approach is being explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 3 years and older Exclusion Criteria: * Pregnancy or positive pregnancy test * Baseline oximetry at MRI visit of less than 90% on room air or less than 90% on a previously prescribed dosage of oxygen delivered by nasal cannula. In some cases of cardiorespiratory disease, if the participant is referred to this research study by their treating physician and considered stable for imaging, the cardiorespiratory criteria will be 5% of their clinical baseline. This should be documented in the research record upon referral of a participant that meets this scenario. * Any condition in the opinion of the investigator that would make the participant unable to tolerate the MRI procedure (e.g., neurocognitive delay, behavioral issues). * Standard MRI exclusions (e.g., metal, incompatible implants).
Where it's running
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States Recruiting
Study contacts
- Principal investigator: Laura Walkup, PhD — Children's Hospital Medical Center, Cincinnati
- Study coordinator: Ashley Borden, MPH
- Email: ashley.borden@cchmc.org
- Phone: 5136360143
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.