AI-assisted chest X-rays to help spot heart and lung problems in the ED

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates whether an AI chest X-ray solution can help ED clinicians make earlier or more accurate diagnoses of heart and lung problems, including COPD, heart failure, and lung cancer. It compares diagnostic outcomes when doctors have access to the AI results versus when they do not. The trial is conducted at the Queen Elizabeth University Hospital in Glasgow and uses the Harrison AI chest X-ray software. Participants are adults undergoing chest X-rays in the ED, with separate focus groups for patients and clinicians. The study has ethical approvals and builds on prior safety testing of the AI tool in multiple regions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Unconsented Use of Harrison CXR Algorithm in Emergency Department (ED):

* Frontal Chest X-Ray (CXR) (AP or PA) acquired in the Queen Elizabeth University Hospital (QEUH) ED
* Patients aged 18 or over
* Appropriate meta data (DICOM) to allow for Harrison CXR processing and secondary capture report provision.

Patient Focus Groups:

* Aged 18 or over
* Able to provide written, informed consent in English.

Clinician Focus Groups:

* Aged 18 or over
* Able to provide written, informed consent in English.
* Working as a doctor, advanced nurse practitioner or advanced clinical practitioner in ED, radiology or downstream medical specialties
* For post-implementation focus groups only, must have at least 4 months experience of working with Harrison CXR algorithm.

Diagnostic Clinic:

* Patients without terminal illness or advanced frailty
* Usual healthcare provider based in NHS GGC

Exclusion Criteria:

Applies to use of unconsented CXRs:

\- Patient has requested that they are removed from the study, or has objected to the use of AI in their routine clinical care and this has been subsequently upheld by the health board.

Applies to invitation to combined diagnostic clinic:

* Patients not available to follow up, including patients i.e. whose the patient's usual care (or onward care following index admission) is out-with NHS GGC.
* Patients who have been referred to palliative care for end-stage disease, or patients with severe frailty (i.e. bedbound) will not be invited to the combined diagnostic clinic

For Patient and Clinician Focus Groups:

* Unable to provide informed written consent in English
* Aged \<18

Where it's running

• Queen Elizabeth University Hospital
  Glasgow, United Kingdom Recruiting

Study contacts

• Principal investigator: David J Lowe — University of Glasgow
• Study coordinator: Clea Du Toit
• Email: clea.dutoit@nhs.scot
• Phone: 0141 314 4328

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.