Proton MRI of Musculoskeletal and Lung Health
Official title: Ultra-Short Echo Time 1H MRI in Individuals With Thoracic Musculoskeletal Disorders
Run by Children's Hospital Medical Center, Cincinnati · NCT07845708 · Data updated 2026-11-12
This study tests MRI techniques to take clearer pictures of the lungs in healthy people and those with lung, muscle, or bone conditions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 5 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Status | Recruiting |
| Started | June 17, 2025 |
| Main results expected | June 2030 |
| Study ends | June 2030 |
| Registry record updated | October 16, 2026 |
| Trial ID | NCT07845708 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals 5 years and older, including healthy volunteers and those with lung, muscle, or bone conditions willing to undergo MRI scans.
✕Probably not a fit
Participants whose conditions do not affect lung imaging or who cannot undergo MRI may see no direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will use advanced MRI methods, including UTE and bSSFP, along with standard MRI, to image the lungs. The study collects MRI images and health information from participants aged 5 and older, spanning healthy individuals and those with various lung, musculoskeletal, or bone diseases. The goal is to better understand how lung structure varies across health and disease and to improve future imaging approaches. This is an observational study at Cincinnati Children's Hospital Medical Center led by Laura Walkup.
Why it matters
Potential benefit: If successful, the study could improve our understanding of lung imaging and help guide future MRI techniques for better diagnosis and monitoring.
How similar studies have gone: Past research has shown promise with advanced lung MRI techniques, supporting the feasibility of this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 5 years Exclusion Criteria: * History of any comorbidity reviewed at the Screening phone call that, in the opinion of the investigator, might confound the results of the study or pose an additional risk to the subject. * Standard MRI exclusion criteria as set forth by the CCHMC Radiology Department and IRC. * Pregnancy
Where it's running
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States Recruiting
Study contacts
- Principal investigator: Laura Walkup, PhD — Children's Hospital Medical Center, Cincinnati
- Study coordinator: Ashley Borden, MPH
- Email: ashley.borden@cchmc.org
- Phone: 5136360143
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
See how well the lungs distribute dissolved xenon gas during MRI in HSCT patients and others
This study tests a special MRI method using hyperpolarized xenon gas to visualize how gas and dissolved xenon move through the lungs in people who have HSCT, respiratory issues, or are healthy controls.
-
Short-term air pollution and exercise effects on children's lungs
This project will test if outdoor exercise on higher-pollution days affects primary-school children's lungs more than resting outdoors.
-
AI-assisted chest X-rays to help spot heart and lung problems in the ED
A computer-aided tool is being tested to see if it helps doctors diagnose heart and lung issues from chest X-rays in adults who visit the emergency department.
-
PneumoRator adhesive chest sensor to monitor breathing after elective surgery
This trial will test a small adhesive chest sensor called the PneumoRator to continuously measure breathing rate in adults having elective surgery who will stay in hospital and go to the Surgical High Dependency Unit.
-
Reducing unnecessary medications in older adults with rheumatic conditions
This project will test whether giving doctors individualized MedSafer reports plus patient EMPOWER brochures helps people 60+ with rheumatic conditions who take five or more regular medications stop or reduce risky medicines.
-
Modifying the respiratory microbiome in cesarean-born infants using vaginal secretions
This study is testing whether using vaginal secretions on healthy cesarean-born infants right after birth can help change their nasal bacteria for the better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.