SC2i Tissue and Data Repository for Critical Illness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational biorepository that prospectively collects blood, urine, cerebrospinal fluid, wound tissue/fluids, and other biological samples from critically ill or seriously injured patients at participating SC2i sites. Healthy volunteers and recovered patients are also enrolled as control subjects. Samples are stored and made available under separate protocols to support development of diagnostic and prognostic tests and clinical decision tools. Consent is obtained from participants or authorized surrogates, and procedures exclude patients for whom sampling would pose undue clinical risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with injury or illness requiring surgical care or treatment in a critical care or emergency setting who are being cared for at SC2I sites (Grady Memorial Hospital, Emory Univeristy Hospital, and Duke University Health Systems)
* Healthy volunteer control subjects to include individuals without any known injury or end-stage organ disease and patients who have recovered from prior injury.
* Ability to understand the purposes and risks of the study and willingly give written informed consent, or in the case of incapacitated patients, a willing surrogate able to give written informed consent.

Exclusion Criteria:

* Any condition that, in the opinion of the attending physician, would place the patient or volunteer subject at undue risk by participating. Specific conditions include but are not limited to anemia prohibitive of phlebotomy, coagulopathy, or technical considerations that would prevent acquisition of sufficient tissue or fluid for clinical use. Acquisition of samples from patients requiring active transfusion or with transfusion-associated coagulopathy will be considered as appropriate study candidates at the discretion of the attending physician.

Where it's running

• Grady Health Systems
  Atlanta, Georgia, United States Recruiting
• Emory University
  Atlanta, Georgia, United States Recruiting
• Walter Reed National Military Medical Center
  Bethesda, Maryland, United States Recruiting
• Duke University Health Systems
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Allan M. Kirk, MD, PhD — Duke University

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.