Long-term GW906 treatment for people with essential hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an open-label extension study lasting up to 2–3 years across multiple centers. Participants who finished the prior GW906 injection trial may enroll after screening and will receive GW906, with initial assignment to Cohort 1 and then Cohort 2 as enrollment progresses. The study does not randomize or compare to a placebo. Safety and efficacy are monitored through ongoing dosing and follow-up assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Completed study treatment and the study in accordance with the protocol for GW906 injection.
* Willing to participate in the study and provide written informed consent.

Exclusion Criteria:

* Secondary hypertension.
* Orthostatic hypotension accompanied by hypotension-related symptoms was observed in a prior study of GW906 injection.
* Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2.5× upper limit of normal (ULN); Total bilirubin \> 1.5 × ULN; International normalized ratio (INR) \> 2.0; Serum potassium \> 5.0 mmol/L or \< 3.5 mmol/L; eGFR≤30 mL/min/1.73m\^2.
* History of any cardiovascular event within 6 months.
* Patients with active malignancy or a history of malignancy.

Where it's running

• Shanghai Jiao Tong University School of Medicine, Ruijin Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Jiguang Wang, Professor
• Email: jiguangwang@rjh.com.cn
• Phone: +86-13764189476

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.