Relationship Between Burst Suppression at Start of Anesthesia and Deepness of TIVA
Official title: The Relationship Between Burst Suppression Observed During Anesthesia Induction and the Bispectral Index Value During the Maintenance Phase of Anesthesia
Run by Amasya University · NCT07557433 · Data updated 2026-11-12
This study checks if early burst suppression in brain activity during anesthesia predicts deeper anesthesia later in the operation for adults having total intravenous anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Amasya University Academic / other |
| Locations | 2 sites (Amasya, Amasya and 1 other locations) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | June 1, 2027 |
| Study ends | August 1, 2027 |
| Registry record updated | July 6, 2026 |
| Trial ID | NCT07557433 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18-75 years old, ASA I–III, scheduled for elective surgery under total intravenous anesthesia, with no neurological disease or ongoing heavy sedative/antiseizure medication use.
✕Probably not a fit
Patients with significant liver or kidney dysfunction, existing neurological disease, or who receive ketamine or dexmedetomidine during surgery may not benefit from the study insights.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study assessing whether an early brain activity pattern called burst suppression, seen at the start of anesthesia, is linked to the depth of anesthesia during surgery. Brain activity is monitored with a forehead BIS sensor, while anesthesia doses are recorded as part of routine care. No changes to anesthesia or standard care are required; researchers will analyze existing monitoring data collected during the procedure. Eligible participants are adults aged 18-75 undergoing elective surgery under TIVA, without certain neurological, hepatic, or renal conditions or specific intraoperative medications. The study aims to improve understanding of how initial brain patterns relate to overall anesthesia depth.
Why it matters
Potential benefit: No direct clinical benefit is promised, but findings could help tailor anesthesia monitoring and potentially improve safety by better predicting anesthesia depth.
How similar studies have gone: Previous research has explored bust suppression and anesthesia depth, with mixed results; this observational approach aims to clarify associations in a real-world setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 75 years * American Society of Anesthesiologists (ASA) physical status I-III * Scheduled for elective surgery * Surgery planned to be performed under total intravenous anesthesia (TIVA) Exclusion Criteria: * Presence of neurological disease * Chronic use of sedative medications or antiepileptic drugs * Severe hepatic or renal dysfunction * Intraoperative administration of ketamine or dexmedetomidine
Where it's running
-
Amasya University Sabuncuoglu Serefeddin Training and Research Hospital
Amasya, Amasya, Turkey (Türkiye) Recruiting -
Izmir Katip Celebi University Ataturk Training and Research Hospital
Izmir, İzmir, Turkey (Türkiye) Not yet recruiting
Study contacts
- Study coordinator: Bülent Meriç Çam, MD
- Email: bulentmericcam@gmail.com
- Phone: +90 (534) 815 6011
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.