Propofol Target-Controlled Infusion Models (Schnider vs Eleveld) During Spinal Surgery
Official title: Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider Target-Controlled Infusion Models. A Randomized Trial
Run by Istanbul University · NCT07586189 · Data updated 2026-11-12
This observational study tests whether two propofol target-controlled infusion models, Schnider and Eleveld, lead to different anesthetic depth and hemodynamic responses during the first 10 minutes of anesthesia induction in adults undergoing spinal surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Istanbul University Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | May 18, 2026 |
| Main results expected | August 15, 2026 |
| Study ends | November 10, 2026 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT07586189 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 and older scheduled for elective spinal surgery at Istanbul University who consent to participate.
✕Probably not a fit
Patients who do not respond to the chosen model may not experience a differential benefit; individual variability could limit observed differences.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults undergoing elective spinal fusion surgery will be assigned to receive propofol via one of two target-controlled infusion models (Schnider or Eleveld) during induction. Standard monitors, including BIS, invasive arterial pressure, ECG, pulse oximetry, and heart rate, will be used, and hemodynamic and depth of anesthesia will be recorded at multiple time points within the first 10 minutes after induction. All participants receive fentanyl, rocuronium, and propofol per protocol; data will compare how each model influences depth of anesthesia and cardiovascular response. This is a randomized prospective observational study focusing on the immediate induction period and comparing pharmacokinetic models rather than therapeutic outcomes.
Why it matters
Potential benefit: If successful, the study could help optimize propofol dosing models to improve stability of anesthesia depth and hemodynamics during induction.
How similar studies have gone: Previous work has explored pharmacokinetic models for propofol, with mixed results on superiority between models; this study adds context in spinal surgery induction.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients scheduled for elective spinal surgery under general anesthesia * Patients who will undergo surgery at the Neurosurgery Department of Istanbul University, Istanbul Faculty of Medicine * Patients aged 18 years or older * Patients who provide written informed consent to participate in the study Exclusion Criteria: * Patients with uncontrolled hypertension * Patients with uncontrolled diabetes mellitus * Patients younger than 18 years of age * Patients who do not provide informed consent to participate in the study
Where it's running
-
Istanbul University
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Tugce Aydin Ozata, MD
- Email: tugceaydin1@gmail.com
- Phone: 009 0533 711 6090
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.