How remifentanil changes propofol-induced burst suppression.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adult patients (ASA I–II) undergoing low- or intermediate-risk elective surgery receive sequential remifentanil and propofol while frontal EEG is recorded. After loss of consciousness, patients are randomized to a medium or high remifentanil effect-site concentration and propofol infusion rates are adjusted to determine the concentration that produces burst suppression. Burst suppression thresholds (propofol concentrations) are compared between the remifentanil dose groups. Routine monitoring and neuromuscular blockade are used to facilitate standardized airway management and surgical conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* American Society of Anesthesiology I or II
* Elective surgery of low or intermediate risk

Exclusion Criteria:

* Neurological disease
* Psychiatric disease
* Use of psychoactive drugs or opioids
* Altered basal state of consciousness
* Allergy to propofol
* Body mass index \> 35 kg/m2
* Pre-existing renal, cardiac and/or hepatic dysfunction
* Patient's refusal to participate

Where it's running

• Centro de Investigación Cínica Avanzada (CICA), Hospital Clinico de la Universidad de Chile
  Santiago, Rm, Chile Recruiting
• Hospital Clinico de la Universidad de Chile
  Santiago, Rm, Chile Recruiting

Study contacts

• Study coordinator: Antonello Penna, MD, PhD
• Email: apenna@uchile.cl
• Phone: +56229788209

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.