Monitoring anesthetic depth during brain tumor surgery
Anesthetic Depth Assessed by Processed EEG (pEEG) - a Comparison of Manual Total Intravenous Anesthesia and Target Controlled Anesthesia in Tumor Resection Via Craniotomy
This study is testing two ways to give anesthesia during brain tumor surgery to see which method helps patients stay at the right level of sedation and recover better afterward.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 126 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Region Skane Academic / other |
| Locations | 1 site (Lund) |
| Trial ID | NCT06922500 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare two methods of administering total intravenous anesthesia (TIVA) using propofol and remifentanil during open resection of brain tumors. The study will assess anesthetic depth through processed EEG (pEEG) monitoring, focusing on the time spent within recommended pEEG levels from induction to the end of surgery. Secondary outcomes include the mean pEEG level, time to regain consciousness post-surgery, and the degree of postoperative sleepiness. The trial is conducted at Lund University Hospital in Sweden, where experienced anesthetic personnel will manage the anesthesia delivery.
Who should consider this trial
Good fit: Ideal candidates are adults scheduled for elective craniotomy to resect a brain tumor.
Not a fit: Patients with cognitive impairments affecting informed consent or those undergoing biopsy without resection may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance postoperative recovery and neurological assessment in patients undergoing brain tumor surgery.
How similar studies have performed: Previous studies have shown promise in using processed EEG for monitoring anesthetic depth, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Elective craniotomy for tumor resection * Adult patient * Consent to participation Exclusion Criteria: * Cognitive impact affecting infrmed consent * brain tumor planned for biopsy without resection Tumor localisation not permitting placement of pEEG electrodes.
Where this trial is running
Lund
- Anesthesia and Intensive Care, Skane University Hospital — Lund, Sweden (Recruiting)
Study contacts
- Principal investigator: Malin Rundgren, MD, PhD — Region Skane
- Study coordinator: Malin Rundgren, MD, PhD
- Email: mailn.rundgren@skane.se
- Phone: +46-46-174242
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.