Monitoring anesthetic depth during brain tumor surgery
Official title: Anesthetic Depth Assessed by Processed EEG (pEEG) - a Comparison of Manual Total Intravenous Anesthesia and Target Controlled Anesthesia in Tumor Resection Via Craniotomy
Run by Region Skane · NCT06922500 · Data updated 2026-11-12
This study is testing two ways to give anesthesia during brain tumor surgery to see which method helps patients stay at the right level of sedation and recover better afterward.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 126 (estimated) |
| Sponsor | Region Skane Academic / other |
| Locations | 1 site (Lund) |
| Status | Recruiting |
| Started | November 21, 2024 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | April 10, 2025 |
| Trial ID | NCT06922500 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults scheduled for elective craniotomy to resect a brain tumor.
✕Probably not a fit
Patients with cognitive impairments affecting informed consent or those undergoing biopsy without resection may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare two methods of administering total intravenous anesthesia (TIVA) using propofol and remifentanil during open resection of brain tumors. The study will assess anesthetic depth through processed EEG (pEEG) monitoring, focusing on the time spent within recommended pEEG levels from induction to the end of surgery. Secondary outcomes include the mean pEEG level, time to regain consciousness post-surgery, and the degree of postoperative sleepiness. The trial is conducted at Lund University Hospital in Sweden, where experienced anesthetic personnel will manage the anesthesia delivery.
Why it matters
Potential benefit: If successful, this study could enhance postoperative recovery and neurological assessment in patients undergoing brain tumor surgery.
How similar studies have gone: Previous studies have shown promise in using processed EEG for monitoring anesthetic depth, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Elective craniotomy for tumor resection * Adult patient * Consent to participation Exclusion Criteria: * Cognitive impact affecting infrmed consent * brain tumor planned for biopsy without resection Tumor localisation not permitting placement of pEEG electrodes.
Where it's running
-
Anesthesia and Intensive Care, Skane University Hospital
Lund, Sweden Recruiting
Study contacts
- Principal investigator: Malin Rundgren, MD, PhD — Region Skane
- Study coordinator: Malin Rundgren, MD, PhD
- Email: mailn.rundgren@skane.se
- Phone: +46-46-174242
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.