REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular Hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This early-phase study tests REGN22530, an experimental drug, in adults with mild-to-moderate POAG or ocular hypertension. It aims to determine safety, how the drug behaves in blood and eye fluids, potential immune reactions, and the effect on intraocular pressure. Participants will receive REGN22530 and undergo monitoring of adverse events, pharmacokinetics, and iop response. The trial helps researchers understand why responses vary among individuals and whether REGN22530 could become a new option for lowering eye pressure.

Why it matters

Who can join: the full rules

Key Inclusion Criteria:

1. Diagnosis of OHT or POAG of mild to moderate severity as described in the protocol
2. Best-Corrected Visual Acuity (BCVA) of ≥35 Early Treatment Diabetic Retinopathy Study (ETDRS) letters (Snellen equivalent of better than or equal to 20/200) in the study eye on day 1
3. BCVA of ≥55 EDTRS letters (Snellen equivalent of better than or equal to 20/80) in the non-study eye on day 1
4. Phakic or pseudophakic with a posterior chamber intraocular lens that has been implanted ≥3 months prior to Screening Visit 1
5. Sufficiently clear ocular media, adequate pupillary dilation and fixation to permit quality posterior segment imaging in the study eye

Key Exclusion Criteria:

Ocular-specific exclusion criteria apply to the Study Eye only, unless otherwise specified.

1. OAG or OHT secondary to pigment dispersion, pseudoexfoliation, trauma, uveitis, neovascularization, a vascular disorder, or steroid use
2. Congenital or traumatic cataract, or visually significant cataract that is likely to require surgical intervention during the study
3. Presence of significant corneal scarring or irregularities that could interfere with reliable IOP measurement
4. Prior incisional or bleb-forming glaucoma surgery, suprachoroidal procedures, Trabecular Meshwork (TM)-stripping Microinvasive Glaucoma Surgery (MIGS), angle-based implants other than iStent or iridectomy/iridotomy as described in the protocol
5. History of Selective Laser Trabeculoplasty (SLT) within 6 months prior to day 1
6. History of transscleral (including micropulse) or endoscopic cyclophotocoagulation within 1 year prior to day 1

Note: Other protocol defined Inclusion/ Exclusion criteria apply

Where it's running

• Advanced Research
  Deerfield Beach, Florida, United States Recruiting

Study contacts

• Study coordinator: Clinical Trials Administrator
• Email: clinicaltrials@regeneron.com
• Phone: 844-734-6643

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pregabalin eye drops vs timolol eye drops for open-angle glaucoma or ocular hypertension

  A doctor-led study tests whether pregabalin eye drops (TB0001) work as well as timolol eye drops to lower eye pressure in adults with glaucoma or high eye pressure.

  Recruiting at 3 sites Phase 2 Tavo Biotherapeutics · Glendale, California and 2 other locations · NCT07913074

• iDose TR implant administration in an office-based eye clinic

  This study tests a travoprost implant (iDose TR) given inside the eye to people with open-angle glaucoma or high eye pressure in an office setting to see if it is safe.

  Recruiting Glaukos Corporation · Austin, Texas · NCT07816692

• Is a preservative-free Bimatoprost 0.01% as effective and safe as Lumigan in POAG or ocular hypertension?

  This study tests whether a preservative-free Bimatoprost 0.01% (YSBP) works as well as Lumigan 0.01% for people with POAG or ocular hypertension.

  Recruiting Phase 3 YS Life Science Co., Ltd. · Beverly Hills, California and 21 other locations · NCT07661329

• Analyzing eye fluid and tissues to find glaucoma-related markers in people with cataracts.

  This study will test whether protein and elemental patterns in eye fluid and tissues taken during cataract surgery differ between people with primary open-angle glaucoma and those without glaucoma.

  Recruiting at 2 sites Military Institute od Medicine National Research Institute · Warsaw and 1 other locations · NCT07462000

• Eye imaging after combined deep sclerectomy and trabeculotomy for open-angle glaucoma

  This study uses ultrasound biomicroscopy to see if specific postoperative eye anatomy after combined deep sclerectomy and trabeculotomy links to better pressure control in people with primary open-angle glaucoma.

  Recruiting Minia University Hospital · Minya, Minya Governorate · NCT07454447

• Direct (non-contact) laser versus standard selective laser for treating glaucoma

  This test compares a newer non-contact laser (DSLT) with the standard SLT to see if it lowers eye pressure just as well in adults with open-angle glaucoma or ocular hypertension.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07408154

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.