Eye imaging after combined deep sclerectomy and trabeculotomy for open-angle glaucoma
Official title: Ultrasound Biomicroscopy Evaluation After Combined Deep Sclerectomy With Trabeculotomy in Primary Open Angle Glaucoma
Run by Minia University Hospital · NCT07454447 · Data updated 2026-11-12
This study uses ultrasound biomicroscopy to see if specific postoperative eye anatomy after combined deep sclerectomy and trabeculotomy links to better pressure control in people with primary open-angle glaucoma.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Minia University Hospital Academic / other |
| Locations | 1 site (Minya, Minya Governorate) |
| Status | Recruiting |
| Started | November 11, 2025 |
| Main results expected | November 2026 |
| Study ends | December 2026 |
| Registry record updated | March 6, 2026 |
| Trial ID | NCT07454447 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (including juvenile-onset cases) with primary open-angle glaucoma who have undergone combined deep sclerectomy with trabeculotomy and have clear ocular media suitable for UBM imaging are ideal candidates.
✕Probably not a fit
Patients with secondary glaucomas, previous filtering surgery in the study eye, or significant media opacities that prevent clear UBM imaging are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study at Minia University Hospital of patients with primary open-angle glaucoma who have undergone combined deep sclerectomy with trabeculotomy. Participants receive postoperative ultrasound biomicroscopy (UBM) to image anterior segment structures such as the intrascleral lake, filtering bleb, and trabeculo-Descemet membrane. Clinical outcomes including intraocular pressure, number of antiglaucoma medications, and other postoperative measures are recorded and correlated with UBM findings. The goal is to identify anatomical features that predict surgical success and to better understand postoperative changes after this combined non-penetrating procedure.
Why it matters
Potential benefit: If successful, the findings could help surgeons predict which patients will achieve better pressure control after the procedure and guide postoperative management to reduce medication use and complications.
How similar studies have gone: UBM has previously been used to correlate anterior segment anatomy with outcomes after non-penetrating glaucoma procedures, so this approach builds on existing imaging work though combined deep sclerectomy with trabeculotomy is less extensively studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of primary open-angle glaucoma (POAG), including juvenile open-angle glaucoma (JOAG). * Patients who underwent combined deep sclerectomy with trabeculotomy. * Clear media allowing adequate ultrasound biomicroscopy imaging. * Written informed consent obtained from the patient . Exclusion Criteria: * Secondary glaucomas (e.g., neovascular, uveitic, traumatic, or angle-closure glaucoma). * Previous glaucoma filtering surgery in the studied eye. * Coexisting ocular pathology affecting UBM assessment (e.g., severe corneal opacity, scleral pathology).
Where it's running
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Minia University Hospital
Minya, Minya Governorate, Egypt Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.