Eye imaging after combined deep sclerectomy and trabeculotomy for open-angle glaucoma
Ultrasound Biomicroscopy Evaluation After Combined Deep Sclerectomy With Trabeculotomy in Primary Open Angle Glaucoma
This study uses ultrasound biomicroscopy to see if specific postoperative eye anatomy after combined deep sclerectomy and trabeculotomy links to better pressure control in people with primary open-angle glaucoma.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Sex | All |
| Sponsor | Minia University Hospital Academic / other |
| Locations | 1 site (Minya, Minya Governorate) |
| Trial ID | NCT07454447 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational study at Minia University Hospital of patients with primary open-angle glaucoma who have undergone combined deep sclerectomy with trabeculotomy. Participants receive postoperative ultrasound biomicroscopy (UBM) to image anterior segment structures such as the intrascleral lake, filtering bleb, and trabeculo-Descemet membrane. Clinical outcomes including intraocular pressure, number of antiglaucoma medications, and other postoperative measures are recorded and correlated with UBM findings. The goal is to identify anatomical features that predict surgical success and to better understand postoperative changes after this combined non-penetrating procedure.
Who should consider this trial
Good fit: Adults (including juvenile-onset cases) with primary open-angle glaucoma who have undergone combined deep sclerectomy with trabeculotomy and have clear ocular media suitable for UBM imaging are ideal candidates.
Not a fit: Patients with secondary glaucomas, previous filtering surgery in the study eye, or significant media opacities that prevent clear UBM imaging are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help surgeons predict which patients will achieve better pressure control after the procedure and guide postoperative management to reduce medication use and complications.
How similar studies have performed: UBM has previously been used to correlate anterior segment anatomy with outcomes after non-penetrating glaucoma procedures, so this approach builds on existing imaging work though combined deep sclerectomy with trabeculotomy is less extensively studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of primary open-angle glaucoma (POAG), including juvenile open-angle glaucoma (JOAG). * Patients who underwent combined deep sclerectomy with trabeculotomy. * Clear media allowing adequate ultrasound biomicroscopy imaging. * Written informed consent obtained from the patient . Exclusion Criteria: * Secondary glaucomas (e.g., neovascular, uveitic, traumatic, or angle-closure glaucoma). * Previous glaucoma filtering surgery in the studied eye. * Coexisting ocular pathology affecting UBM assessment (e.g., severe corneal opacity, scleral pathology).
Where this trial is running
Minya, Minya Governorate
- Minia University Hospital — Minya, Minya Governorate, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.