Monitoring anesthesia depth and pain response during induction in children
Official title: Monitoring the Depth of Anesthesia and Nociception During the Induction of General Anesthesia in Pediatric Patients: a Prospective Observational Study
Run by Brno University Hospital · NCT07245654 · Data updated 2026-11-12
This project will try a bedside monitor called Conox to measure how deeply children (ages 1–19) are anesthetized and how well their pain is controlled when general anesthesia is started.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 1 Year to 19 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Brno University Hospital Academic / other |
| Locations | 1 site (Brno) |
| Status | Recruiting |
| Started | November 10, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | November 24, 2025 |
| Trial ID | NCT07245654 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pediatric patients aged 1–19 years undergoing elective surgery under general anesthesia with expected duration over 30 minutes and availability of CONOX monitoring.
✕Probably not a fit
Patients having very short procedures, those receiving ketamine, emergency cases, or those at sites without CONOX monitoring are unlikely to benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study using the Conox device to continuously monitor depth of anesthesia (qCON index) and analgesia during induction of general anesthesia in pediatric patients. Electrodes are placed on the forehead before induction and data are recorded throughout airway management and the operation, with no change to standard anesthetic care. The team will record opioid use, airway management method, occurrences of burst suppression, and postoperative delirium in the recovery room. No experimental interventions are given; the study compares monitored indices with clinical events to characterize monitoring performance.
Why it matters
Potential benefit: If successful, this monitoring approach could help reduce intraoperative awareness episodes and lower the risk of postoperative delirium and inadequate pain control in children.
How similar studies have gone: Processed EEG monitors like BIS and related indices have shown usefulness in adults for guiding anesthetic depth, but pediatric data are more limited and the qCON application in children is less well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pediatric patients (age 1-19 years) indicated for surgery under general anesthesia with airway management (laryngeal mask, orotracheal intubation, nasotracheal intubation) * CONOX monitoring available Exclusion Criteria: * Age out of range * Use of ketamine during anesthesia care (premedication, analgesic, anesthetic) * Expected duration of surgery less than 30 minutes * CONOX monitoring unavailable
Where it's running
-
University Hospital Brno
Brno, Czechia Recruiting
Study contacts
- Principal investigator: Petr Štourač, prof.MD.Ph.D — Brno University Hospital
- Study coordinator: Tereza Bonischova, MD
- Email: musilovate@gmail.com
- Phone: 00420724253223
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Guiding children's anesthesia with processed EEG to reduce postoperative behavior changes
This tests whether using processed EEG monitoring during surgery reduces long-term postoperative behavior changes in children aged 3–10 undergoing common pediatric surgeries.
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qCON/qNOX-guided anesthesia for thyroidectomy
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This will test whether giving higher (80%), medium (50%), or lower (≤30%) oxygen during and right after major surgery changes wound infection rates and recovery for adults having longer operations.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.