Probiotics vs Antibiotics as an add-on to non-surgical periodontal care in adult smokers with stage II, grade B periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial compares two systemic add-ons—probiotics and antibiotics—used with scaling and root planing in adult smokers diagnosed with stage II, grade B periodontitis. Outcomes include clinical measures of periodontal health and biochemical markers in gingival crevicular fluid, such as inflammatory mediators. The study aims to see if probiotics can offer similar or superior benefits to antibiotics by restoring microbial balance and modulating inflammation. Participants are adults aged 25-50 with specified disease characteristics, and the treatment is delivered in an institutional setting in Cairo. The trial reflects an interest in adjuvant therapies that may reduce tissue destruction while promoting periodontal stability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 25-50 years
* Periodontitis male patients diagnosed as they having Stage II, Grade B periodontitis
* Clinical attachment loss 3-4 mm
* Radiographic bone loss in coronal third.
* Current smokers or non-smokers.

Exclusion Criteria:

* Systemic diseases affecting periodontal health.
* Periodontal therapy within last 6 months.
* Use of antibiotics, probiotics or anti-inflammatory medication within last 3 months.
* History of allergy to the prescribed study medications.
* Patients unwilling to comply with study instructions or follow-up visits

Where it's running

• October 6 University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Ahlam A Al-shawafi, B.Sc
• Email: Periodentistahlam@gmail.com
• Phone: 00201156330099

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.