Ozone Gel vs Chlorhexidine Gel as an add-on to non-surgical cleaning for smokers with Stage II periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two adjunct gels used with standard scaling and root planing in smoker patients with Stage II Grade B periodontitis. Participants receive conventional periodontal cleaning alone, or with either chlorhexidine or ozone gel as an adjunct. The trial also includes a non-smoker comparator group with the same diagnosis to provide baseline context. Outcomes include clinical and biochemical measures of periodontal status to see if the gels offer additional benefit beyond standard therapy. The study builds on known antimicrobial and anti-inflammatory properties of chlorhexidine and ozone to assess real-world effectiveness in a smoker population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female patients aged 25-45 years
* Diagnosed with Stage II Grade B periodontitis
* Clinical attachment loss of 3-4 mm
* Radiographic bone loss confined to the coronal third of the root
* Either smokers or non-smokers

Exclusion Criteria:

* Systemic diseases affecting periodontal health
* Pregnancy or lactating female
* Periodontal therapy within the last 6 months
* Use of antibiotics or anti-inflammatory medication during the last

Where it's running

• October 6 University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Sara A Agha, B.D.S
• Email: Ahmedagha55aa@gmail.com
• Phone: 00201025536848

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.