PRF plus corticosteroids vs PRF alone vs standard care for impacted lower wisdom teeth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized trial, 60 adults undergoing impacted mandibular third molar extraction are assigned to three groups: standard treatment, PRF alone, and PRF combined with corticosteroid. Postoperative outcomes—pain, facial swelling, and limited mouth opening—are measured on days 1, 2, 3, and 7 after surgery. The goal is to determine if PRF and/or its combination with corticosteroids improve recovery compared with standard care. The study uses typical postoperative medications and oral hygiene measures as part of routine care. Results may influence postoperative management for impacted third molar extractions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 years and older.
* Patients with good general health
* Patients with complete clinical and radiographic examination (panoramic radiograph/CBCT if applicable)
* Patients willing and able to attend all postoperative follow-up visits

Exclusion Criteria:

* Patients with systemic diseases that may impair wound healing (e.g., uncontrolled diabetes, immunodeficiency).
* Pregnant or breastfeeding women.
* Patients with acute infection, abscess, or pericoronitis at the surgical site.
* Patients with a history of allergy or contraindication to corticosteroids, local anesthetics, or prescribed medications.
* Patients using corticosteroids, anticoagulants, immunosuppressive drugs, or bisphosphonates.
* Patients with bleeding disorders.
* Patients with previous radiotherapy to the head and neck region.
* Patients unable or unwilling to comply with the study protocol or attend follow-up visits.

Where it's running

• Final International University Faculty of Dentistry
  Nicosia, Cyprus Recruiting

Study contacts

• Study coordinator: Meliz Kneebone, DDS
• Email: meliz-95@hotmail.com
• Phone: +905338425731

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.