Preserving lung volume during extubation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates two different approaches to extubation in patients weaning from mechanical ventilation, focusing on techniques that aim to preserve lung volume. Patients will be randomized to either a standard method with continuous suctioning or a lung volume preservation method without suctioning. The effectiveness of these approaches will be assessed using lung ultrasound to measure lung aeration and collapse. The goal is to determine which method yields higher rates of successful extubation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients\> 18 years who meet weaning criteria (see below)
* More than 24 hours of mechanical ventilation (MV)
* Signed Informed Consent by a substitute decision maker (SDM).

Weaning Criteria:

* Suitable cough (Ability to raise secretions to the endotracheal tube) (or Maximal inspiratory pressure (MIP) \< -15 cmH2O).
* Absence of excessive secretions (\<3 aspirations in the last 8 hours).
* Resolution or improvement of the pathology that led to intubation.
* Clinical stability (Heart Rate (HR) \<140 bpm, Systolic Blood Pressure (SBP) 90-160, without vasopressors or at minimum doses).
* Adequate oxygenation (SatO2\> 90% with Inspiratory Fraction of oxygen (FiO2) \<0.4).
* Adequate ventilatory mechanics (Respiratory rate (RR) \<35 rpm, Tidal Volume (TV) \> 5 ml / kg, RR / TV \<100 rpm/l).
* Confident awareness level (Glasgow Coma Scale (GCS)\> 13).

Exclusion Criteria:

* tracheostomy, do-not-reintubate orders, decision of the responsible physician (e.g., due to a preference for a particular weaning technique according to the underlying pathology), absence of informed consent, mental incapacity without legal representation.
* For ultrasound assessment: skilled explorer not present at the time of the SBT, inadequate ultrasound window. Known diaphragmatic paralysis.

Where it's running

• Althaia Xarxa Assistencial
  Manresa, Bacelona, Spain Recruiting

Study contacts

• Principal investigator: Carlos Subira, PhD — Althaia Xarxa Assitencial de Manresa
• Study coordinator: Carlos Subira, PhD
• Email: carlessubira@gmail.com
• Phone: +346479392053

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• heepSync: synchronized electrical stimulation of breathing muscles for adults on mechanical ventilation

  This trial tests whether the heecap heepSync algorithm can safely sync electrical stimulation to breathing muscles in adults on mechanical ventilation.

  Recruiting at 3 sites Tesai Care SL · Barcelona, Barcelona and 2 other locations · NCT07363902

• Characterization of weaning practices in ICUs in Global South countries

  This observational study tests how adult ICU patients on mechanical ventilation who are starting to wean are extubated, observing them for 7 days after extubation and until hospital discharge or death.

  Recruiting Hospital do Coracao · Joinville, Santa Catarina · NCT07337408

• Monitoring diaphragm electrical activity and breathing effort during ventilator weaning

  We will see if surface diaphragm EMG, esophageal pressure, and oxygen use measured during a spontaneous breathing trial can predict who will fail to wean from the ventilator in the ICU.

  Recruiting Leiden University Medical Center · Leiden · NCT07109570

• Using levosimendan to shorten time on a ventilator

  This will test whether giving levosimendan to adults in the ICU who have failed a breathing trial helps them get off the ventilator sooner.

  Recruiting at 6 sites Phase 4 Radboud University Medical Center · Arnhem, Gelderland and 7 other locations · NCT07105202

• How differences in lung stiffness and breathing pressures affect getting off the ventilator after a tracheostomy

  This project will test whether measurements of regional lung compliance and transpulmonary driving pressure using electrical impedance tomography and esophageal pressure can explain why some tracheostomized patients on prolonged mechanical ventilation cannot be weaned.

  Recruiting National Taiwan University Hospital · Taipei · NCT07003672

• Impact of low phosphate levels on weaning off mechanical ventilation

  This study is testing if giving a phosphate supplement can help patients with low phosphate levels breathe better and get off mechanical ventilation more easily.

  Recruiting Peking Union Medical College · Beijing · NCT06754670

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.