How differences in lung stiffness and breathing pressures affect getting off the ventilator after a tracheostomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project will enroll adult tracheostomized patients who have been on mechanical ventilation for at least 14 days in the subacute respiratory care ward at National Taiwan University Hospital. Participants will undergo electrical impedance tomography (EIT) and esophageal pressure measurements to quantify regional lung compliance, overinflation or collapse, and transpulmonary driving pressure during weaning and spontaneous breathing trials. Researchers will correlate pixel-level compliance changes and measured pressures with failure of the final spontaneous breathing test and difficulty liberating from the ventilator. The aim is to identify respiratory physiology markers that predict weaning failure and to inform individualized ventilation or rehabilitation strategies for prolonged mechanical ventilation patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Post-tracheostomy patients who are transferred to the subacute respiratory care ward of National Taiwan University Hospital must use respirators for at least 14 days;
* Be at least 20 years old;
* The oxygen concentration required when using the respirator does not exceed 50%

Exclusion Criteria:

* The vital signs are unstable or require continuous use of vasopressors;
* Pregnancy;
* Chronic obstructive pulmonary disease or asthma;
* Those who have contraindications to the placement of esophageal pressure balloons, such as abnormal blood coagulation, esophageal varices, and those who have undergone esophageal or gastric surgery in the past six months;
* Those who have contraindications to the use of electrical impedance tomography, such as heart rhythm regulators.

Where it's running

• National Taiwan University Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Study coordinator: Jih-Shuin Jerng, MD, PhD, Principal Investigator
• Email: jsjerng@ntu.edu.tw
• Phone: +886-2-23123456

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.