Monitoring blood flow changes during controlled low blood volume conditions
Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia
This study is testing how lowering blood volume affects blood flow in healthy people to find the best ways to monitor these changes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 20 Years to 45 Years |
| Sex | All |
| Sponsor | Yale University Academic / other |
| Locations | 1 site (New Haven, Connecticut) |
| Trial ID | NCT03592290 on ClinicalTrials.gov |
What this trial studies
This research aims to monitor the effects of lower body negative pressure (LBNP) on hemodynamics by inducing controlled hypovolemia in healthy volunteers. The study will assess changes in central and peripheral waveforms, including those from pulse oximeters placed on various body sites such as the finger, ear, forehead, and nose. Additionally, blood pressure, cerebral oximetry, and peripheral venous pressure will be measured to identify the most effective monitoring sites for hypovolemia. The findings could enhance our understanding of hemodynamic instability and improve monitoring techniques.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy volunteers aged 20-45 without any underlying health conditions.
Not a fit: Patients with coronary artery disease, diabetes, epilepsy, hypertension, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for monitoring blood volume changes, which is crucial for managing patients with hemodynamic instability.
How similar studies have performed: While this approach is observational and may not have been extensively tested in this specific context, similar studies have shown promise in monitoring hemodynamic changes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \* Healthy volunteers aged 20-45 with Exclusion Criteria: * Pregnant women * Under 20 years of age * Subjects with coronary artery disease, diabetes, epilepsy and hypertension
Where this trial is running
New Haven, Connecticut
- John B. Pierce Laboratory — New Haven, Connecticut, United States (Recruiting)
Study contacts
- Principal investigator: Aymen Alian, MD — Yale University
- Study coordinator: Aymen Alian, MD
- Email: aymen.alian@yale.edu
- Phone: 203-785-2802
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.