Monitoring blood flow changes during controlled low blood volume conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to monitor the effects of lower body negative pressure (LBNP) on hemodynamics by inducing controlled hypovolemia in healthy volunteers. The study will assess changes in central and peripheral waveforms, including those from pulse oximeters placed on various body sites such as the finger, ear, forehead, and nose. Additionally, blood pressure, cerebral oximetry, and peripheral venous pressure will be measured to identify the most effective monitoring sites for hypovolemia. The findings could enhance our understanding of hemodynamic instability and improve monitoring techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\* Healthy volunteers aged 20-45 with

Exclusion Criteria:

* Pregnant women
* Under 20 years of age
* Subjects with coronary artery disease, diabetes, epilepsy and hypertension

Where it's running

• John B. Pierce Laboratory
  New Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Aymen Alian, MD — Yale University
• Study coordinator: Aymen Alian, MD
• Email: aymen.alian@yale.edu
• Phone: 203-785-2802

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.