Home › Trials › NCT07754656
Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Adapted CPR Strategy for Adults in Cardiac Arrest

Official title: Adapted CPR (aCPR) a Bundle of Measures for Out of Hospital Cardiac Arrest (OHCA) Patients

Run by Johannes Kepler University of Linz · NCT07754656 · Data updated 2026-11-12

This trial tests whether a modified advanced life support algorithm improves return of spontaneous circulation in adults who suffer a cardiac arrest before reaching the hospital.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment216 (estimated)
SponsorJohannes Kepler University of Linz
Academic / other
Locations1 site (Linz, Upper Austria)
StatusRecruiting
StartedJanuary 28, 2026
Main results expectedJanuary 28, 2029
Study endsMarch 28, 2029
Registry record updatedAugust 10, 2026
Trial IDNCT07754656 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 years and older who experience prehospital cardiac arrest and can be enrolled within 21 minutes of resuscitation onset.

Probably not a fit

Patients outside enrollment windows, with contraindications to Lucas 3, extremely prolonged resuscitation with very low etCO2 on arrival, or futility exclusions, may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-centre randomized controlled trial compares two advanced cardiac life support approaches for adults with prehospital cardiac arrest. Participants are randomized on scene to receive either standard ALS per local protocols or a modified aCPR algorithm that includes mechanical chest compression with the LUCAS 3 device, head-up CPR, an impedance threshold device, and arterial line monitoring. The study focuses on ROSC frequency as the primary outcome while adhering to predefined inclusion and exclusion criteria based on age, resuscitation duration, and physiological parameters. Conducted at Kepler University Hospital in Linz with support from Red Cross Upper Austria and Johannes Kepler University, the trial aims to determine if the new algorithm offers a meaningful benefit over standard care.

Why it matters

Potential benefit: If successful, the modified ALS algorithm could increase the chance of ROSC and improve survival through on-scene improvements in resuscitation efficiency.

How similar studies have gone: Previous studies with novel ALS components have shown mixed results; this trial tests a combined approach in a controlled setting to establish effectiveness.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age\> 18 years
* time of resuscitation \<21 minutes when enrollement starts

Exclusion Criteria:

* obvious pregnancy
* contraindications for the use of Lucas 3
* time of resuscitation \>21 minutes and etCO2 \<15 mmHg upon arrival of the emergency physician on scene
* Exclusion from the emergency physician from study due to futility.

Where it's running

  • Kepler University Hospital
    Linz, Upper Austria, Austria     Recruiting

Study contacts

  • Principal investigator: Jens Meier, Univ. Prof. — Kepler University Hospital / Johannes Kepler University

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
Cardiac Arrest (CA) 37Johannes Kepler University of Linz 6
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.