Peer-led Dynamic Choice HIV Prevention for Women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cluster randomized study evaluating a peer-led Dynamic Choice HIV Prevention intervention tailored for women at elevated risk in Western and South-Central Uganda. It compares the intervention to standard HIV prevention services and looks at both effectiveness and implementation outcomes. Participants are HIV-negative women aged 15 and older who may be eligible for PrEP/PEP or work in bars or guesthouses. The study uses a hybrid design to assess how well the program works in real-world settings and how it can be implemented at scale. Lead sponsor is UCSF, with collaborations including NIMH and Ugandan partners.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \>=15 years (with parent/guardian consent required for age 15 to \<18 years)
2. Female sex at birth;
3. HIV negative by country-standard testing algorithm;
4. Elevated risk of HIV exposure, defined as at least 1 of the following: a) eligible for PrEP/PEP based on Uganda Ministry of Health Guidelines or b) work in bar or guesthouse

Exclusion Criteria:

1. Contraindication to recommended PrEP/PEP regimen per Ministry of Health guidelines
2. Participation in another HIV prevention study
3. Aged 15 to \<18 years with no parent or guardian to provide consent

Where it's running

• Infectious Diseases Research Collaboration
  Kampala, Uganda Recruiting

Study contacts

• Principal investigator: Catherine Koss, MD — University of California, San Francisco
• Study coordinator: Catherine Koss, MD
• Email: catherine.koss@ucsf.edu
• Phone: 415-476-4082

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.