Improving long-term medication adherence for HIV treatment
Official title: INcentives and ReMINDers to Improve Long-term Medication Adherence
Run by Rand · NCT06949774 · Data updated 2026-11-12
This study is testing whether daily text messages and rewards can help people starting HIV treatment stick to their medication plan over the long term.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 550 (estimated) |
| Sponsor | Rand Academic / other |
| Locations | 1 site (Kampala) |
| Status | Recruiting |
| Started | April 2, 2025 |
| Main results expected | December 31, 2028 |
| Study ends | October 31, 2029 |
| Registry record updated | July 14, 2026 |
| Trial ID | NCT06949774 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have recently started ART and can communicate in English or Luganda.
✕Probably not a fit
Patients who are not mentally fit to consent or cannot consistently use the adherence measurement device will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to enhance long-term adherence to antiretroviral treatment (ART) among individuals starting therapy for HIV. It employs a Sequential, Multiple Assignment, Randomized Trial (SMART) design to test the effectiveness of daily text messages and incentivization strategies in promoting medication adherence. Participants will be randomized to receive either standard care or daily text messages, with those showing low adherence being re-randomized to receive various incentive schemes. The study will monitor adherence over 18 months to identify the most effective and cost-efficient intervention strategies.
Why it matters
Potential benefit: If successful, this approach could significantly improve medication adherence among HIV patients, leading to better health outcomes and reduced transmission rates.
How similar studies have gone: Previous studies have shown promise in using behavioral economics and text messaging to improve medication adherence, suggesting this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female clients age 18 and older. * Started ART at Mildmay or another clinic within the preceding 2 months * Able to speak and understand either English or Luganda. * Have their own cell phone or have consistent access to someone else's phone. * Willing to receive daily text messages for the 6 months of intervention duration. * Willing and able to use the WisePill device distributed for adherence verification for the duration of the study. Exclusion Criteria: * Not mentally fit to consent. * Language other than Luganda or English. * Not willing to consistently use the Wisepill device for adherence measurement.
Where it's running
-
Mildmay Uganda
Kampala, Uganda Recruiting
Study contacts
- Principal investigator: Sebastian Linnemayr, Ph.D — Rand
- Study coordinator: Yvonne Karamagi Site Principal Investigator
- Email: yvonne.karamagi@mildmay.or.ug
- Phone: +256312210200
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.