Paracetamol Use in ICU Patients: Does It Change Blood Pressure?
Official title: Prospective Study Evaluating the Hemodynamic Impact of PAracetamol Administration in Patients Hospitalized in the REAnimation Intensive Care Unit
Run by Centre Hospitalier Universitaire de Nice · NCT06430697 · Data updated 2026-11-12
This study tests whether intravenous or oral paracetamol affects blood pressure in adults in the ICU who already have an arterial line.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Status | Recruiting |
| Started | February 3, 2025 |
| Main results expected | August 2027 |
| Study ends | September 2028 |
| Registry record updated | May 26, 2026 |
| Trial ID | NCT06430697 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older with an arterial line in the ICU who are prescribed paracetamol by their treating clinician.
✕Probably not a fit
Patients who do not experience blood pressure changes or who do not receive paracetamol are unlikely to benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will observe adults in the ICU who receive paracetamol to see how often significant arterial hypotension occurs within one hour after dosing. They will look at factors like age, body weight, pain, vasopressor use, and sedatives to see if they are linked to blood pressure changes. The study is observational in nature and involves documenting events around paracetamol administration; no randomization or experimental treatments are performed. Data collection focuses on real-world use and potential associations between paracetamol and arterial tension. The aim is to better understand safety when paracetamol is given to critically ill patients.
Why it matters
Potential benefit: If successful, the findings could help clinicians anticipate and manage low blood pressure after paracetamol in the ICU.
How similar studies have gone: Previous data suggest possible arterial hypotension with IV paracetamol, but evidence in ICU patients remains limited and mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Inclusion: * 18 years of age or older * Patient with arterial catheter * Indication of paracetamol's administration by the patient's attending practitioner. * No opposition to patient or support person participation in the study if the patient is unable to participate ExclusionCriteria: * No Social Security Patient * Pregnant or nursing patient. * Patient with a legal protection measure * Hypersensitivity and/or allergy to paracetamol. * Contraindication to the use of paracetamol. * Patient opposition to health data collection.
Where it's running
-
CHU de NICE ARCHET
Nice, France Recruiting
Study contacts
- Study coordinator: Kamila BURDZENIDZE, Study nurse
- Email: crc@chu-nice.fr
- Phone: 04 92 03 92 20
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Measuring cerebral blood flow changes during blood pressure variations in ICU patients
This study is trying to see how changes in blood pressure affect blood flow to the brain in ICU patients, especially looking at those with and without heart risks.
-
Observing recovery from weakness after severe respiratory and cardiac failure
This study looks at how people who had severe breathing and heart problems recover from weakness after being in intensive care and on a special life-support machine, to see what helps or hinders their recovery.
-
Capillary vs arterial blood gas analysis in COPD or APE patients with respiratory distress
This study tests whether a capillary blood gas test can replace the arterial test in adults with COPD flare or cardiogenic pulmonary edema who need non-invasive ventilation.
-
BiP inhibitor BPR001-615 in colorectal adenocarcinoma
This study tests whether the BiP inhibitor BPR001-615 can affect cancer cells from colorectal adenocarcinoma, in patients who will have surgical removal of their tumor at Nice University Hospital.
-
Three CT Signs of Nerve-Root Suffering in Low-Back Sciatica: How Often They Occur in Patients Referred for CT-Guided Nerve-Root Infiltration
This study tests whether three specific CT signs align with the nerve root causing symptoms in adults with low-back sciatica who are scheduled for CT-guided nerve-root infiltration.
-
Innate immune cells in abdominal inflammation: observing their behavior in patients undergoing digestive surgery
This study tests how innate immune cells behave during inflammatory episodes by analyzing non-invasively collected abdominal fluid from adults having digestive surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.