Capillary vs arterial blood gas analysis in COPD or APE patients with respiratory distress
Official title: Comparison of Arterial and Capillary Blood Gas Analyses in Patients With Respiratory Distress Due to COPD or APE
Run by Centre Hospitalier Universitaire de Nice · NCT07835945 · Data updated 2026-11-12
This study tests whether a capillary blood gas test can replace the arterial test in adults with COPD flare or cardiogenic pulmonary edema who need non-invasive ventilation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 65 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Status | Recruiting |
| Started | September 28, 2026 |
| Main results expected | March 24, 2027 |
| Study ends | March 24, 2027 |
| Registry record updated | October 2, 2026 |
| Trial ID | NCT07835945 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with COPD exacerbation or cardiogenic APE admitted to emergency care and requiring non-invasive ventilation.
✕Probably not a fit
Patients for whom capillary sampling is not feasible or accurate, or those not meeting NIV indications, may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In adults with respiratory distress due to COPD exacerbation or cardiogenic acute pulmonary edema requiring non-invasive ventilation, arterial blood gas analysis is the current standard but is invasive. The study investigates capillary blood gas analysis as a less invasive alternative to assess gas exchange and guide NIV. Data collected compare capillary results with arterial results to determine equivalence and practical utility in the emergency setting. The trial is conducted at CHU de Nice under real-world emergency care conditions.
Why it matters
Potential benefit: If capillary testing proves reliable, patients could experience less pain and fewer invasive procedures while still receiving appropriate NIV treatment decisions.
How similar studies have gone: Previous work suggests capillary sampling has potential but evidence in this specific respiratory distress/NIV context is limited and not definitive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients older than 18 years old * Patients admitted in the emergency care unit with an exacerbation of COPD or a cardiogenic APE requiring a non-invasive ventilation (i.e. for COPD patients pH\< 7.35, for APE patients: PCO2 \> 45 mmHg) * Patients affiliated to a social security system Exclusion Criteria: * Patients for which a non-invasive ventilation was initiated upon pre-hospital care * Contraindication for non-invasive ventilation * Patients for which non-invasive ventilation is not indicated * Patients for which capillary or arterial blood gas analyses are impossible * Adults subject to legal guardianship (guardianship, conservatorship) * Pregnant women * Patients with a congenital heart disease
Where it's running
-
CHU de Nice
Nice, France Recruiting
Study contacts
- Study coordinator: Nathalie Ducot, MD-PhD
- Email: ducot.n@chu-nice.fr
- Phone: +33 (0)4 92 03 32 42
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.