Measuring cerebral blood flow changes during blood pressure variations in ICU patients
Official title: Cerebral Perfusion Variation During Blood Pressure Changes in ICU: Relationship Between Transcranial Doppler, Frontal EEG and Cerebral Oximetry: a Prospective Observational Study
Run by Assistance Publique - Hôpitaux de Paris · NCT05804773 · Data updated 2026-11-12
This study is trying to see how changes in blood pressure affect blood flow to the brain in ICU patients, especially looking at those with and without heart risks.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 92 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris, France) |
| Status | Recruiting |
| Started | July 9, 2023 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | February 19, 2026 |
| Trial ID | NCT05804773 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult patients over 18 years old who require admission to the intensive care unit.
✕Probably not a fit
Patients under 18 years of age, pregnant women, or those unable to express their will regarding participation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess how cerebral perfusion varies in patients admitted to the intensive care unit (ICU) during controlled blood pressure changes. It focuses on non-invasively measuring cerebral blood velocity using transcranial pulsed Doppler (TCD) to ensure that blood pressure levels remain within recommended safety standards during sedation. The study will compare cerebral perfusion and oxygen adequacy in patients with and without cardiovascular risk factors, providing insights into the thresholds for maintaining organ perfusion. The findings could help refine blood pressure management strategies in critically ill patients.
Why it matters
Potential benefit: If successful, this study could lead to improved blood pressure management protocols, enhancing organ perfusion and patient outcomes in the ICU.
How similar studies have gone: While the approach of measuring cerebral perfusion during blood pressure variations is established, this specific study's methodology and focus on ICU patients may provide novel insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (\> 18 years old) * Requiring an intensive care unit admission * Informed patient who has expressed his/her non-opposition to participating in this research or, if applicable, trusted person/relative of patient unable to express his/her wishes Exclusion Criteria: * Patients under 18 years of age. * Patient, or if applicable, trusted person / close relative / parent of patient unable to express his/her will, opposed to participation in the protocol * Pregnant woman * Patient under judicial protection * Patient not affiliated to a social health system
Where it's running
-
Hôpital Lariboisière
Paris, France, France Recruiting
Study contacts
- Principal investigator: Fabrice VALLEE, MD, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Joaquim MATEO, MD
- Email: joaquim.mateo@aphp.fr
- Phone: 149958374
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.