Innate immune cells in abdominal inflammation: observing their behavior in patients undergoing digestive surgery
Official title: Inflammatory Dynamics of Innate Immune Cells
Run by Centre Hospitalier Universitaire de Nice · NCT07633327 · Data updated 2026-11-12
This study tests how innate immune cells behave during inflammatory episodes by analyzing non-invasively collected abdominal fluid from adults having digestive surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice, Alpes-Maritimes) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | May 31, 2027 |
| Study ends | May 31, 2028 |
| Registry record updated | June 8, 2026 |
| Trial ID | NCT07633327 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 undergoing digestive surgery who are not on immunomodulatory therapies.
✕Probably not a fit
Patients on immunomodulatory treatments or without inflammatory episodes may derive no direct benefit from participating.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study collects non-invasively obtained peritoneal lavage fluid from patients aged 18 to 80 undergoing digestive surgery. The fluid and its cells will be separated, with cytokine levels measured by ELISA and immune cell states characterized by flow cytometry. Researchers will describe the inflammatory markers and the functional profiles of innate immune cells under the patient’s current physiological condition. Findings aim to map immune cell dynamics during inflammation in a surgical context. The study does not involve experimental therapies beyond standard surgical care.
Why it matters
Potential benefit: If successful, the study could improve understanding of immune responses during abdominal inflammation and inform future strategies for monitoring or management.
How similar studies have gone: Previous observational work has shown that profiling peritoneal immune cells and cytokines can reveal inflammatory patterns, supporting the potential value of this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients undergoing digestive surgery from 18 to 80 years old. Exclusion Criteria: * Patients under immunomodulatory treatments
Where it's running
-
CHU de Nice
Nice, Alpes-Maritimes, France Recruiting
Study contacts
- Study coordinator: Zakariya Caillot
- Email: zakariya.caillot@etu.unice.fr
- Phone: 0489153825
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.