Condition

Symptomatic Irreversible Pulpitis (SIP) clinical trials and research

• 6Clinical trials
• 4Countries

Newest Symptomatic Irreversible Pulpitis (SIP) clinical trials

All recruiting trials (6)

• Pain relief after a single-visit root canal: comparing acetaminophen, NSAIDs, and trypsin-chymotrypsin combo

  This trial tests whether acetaminophen alone, an NSAID, or a combination of trypsin-chymotrypsin with acetaminophen best relieves pain after a single-visit root canal in adults with symptomatic irreversible pulpitis.

  Recruiting Early Phase 1 Dow University of Health Sciences · Karachi, Sindh · NCT07759349

• Partial pulpotomy in mature lower molars with SIP using calcium hypochlorite vs sodium hypochlorite

  This trial tests whether washing the exposed pulp with calcium hypochlorite or with sodium hypochlorite during partial pulpotomy in adults helps healing and reduces pain.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07748676

• Local dexamethasone to improve anesthesia in painful irreversible pulpitis

  This trial tests whether giving dexamethasone under the gum or between tooth-supporting ligaments helps make anesthetic blocks work better and reduce pain in adults with painful irreversible pulpitis in the lower molars.

  Recruiting Marmara University · Istanbul · NCT07672873

• Using intraoral cold to improve numbness in lower front teeth

  This trial will see if applying cold inside the mouth helps buccal infiltration anesthesia work better for adults with symptomatic irreversible pulpitis in a lower front tooth.

  Recruiting Phase 4 Ondokuz Mayıs University · Samsun, Atakum · NCT07517367

• Comparing MTA versus Biodentine for complete pulpotomy in painful molars

  This will test whether MTA or Biodentine works better to relieve pain and preserve the tooth in adults (18–40) with symptomatic irreversible pulpitis in a molar.

  Recruiting at 2 sites Dow University of Health Sciences · Karachi, Sindh and 1 other locations · NCT07483788

• Intraligamentary injection versus inferior alveolar nerve block for painful lower molar pulpitis

  This trial will see if an intraligamentary injection or an inferior alveolar nerve block gives better pain control for adults having root canal treatment of a painful lower molar with symptomatic irreversible pulpitis.

  Recruiting at 2 sites Aula Dental Avanzada · Ferrol, A coruña and 1 other locations · NCT07130760

Related topics

Quick answers

How many Symptomatic Irreversible Pulpitis (SIP) clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in Turkey (Türkiye) (2 trials), Pakistan (2 trials), Spain (1 trial), India (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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