Using intraoral cold to improve numbness in lower front teeth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized clinical trial enrolls adults with symptomatic irreversible pulpitis in a single-rooted mandibular incisor and compares buccal infiltration anesthesia alone, buccal infiltration plus intraoral cryotherapy, and the use of supplemental lingual infiltration as needed. Cryotherapy involves local cold application inside the mouth before or during anesthetic delivery to reduce nerve conduction and local inflammation. Primary outcomes include anesthetic success measured by pain scores, responses to pulp testing, and the need for supplemental injections during endodontic treatment. The goal is to determine whether adding intraoral cryotherapy can improve pain control and reduce the requirement for additional injections in mandibular incisor anesthesia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 to 60 years
* Classified as ASA Physical Status I or II
* Presence of symptomatic irreversible pulpitis in a single-rooted mandibular incisor tooth
* Preoperative pain score ≥8 on the Numerical Rating Scale (NRS) and Wong-Baker FACES scale
* Positive response to cold test and electric pulp testing
* Absence of periapical pathology on preoperative periapical radiograph
* No analgesic intake within 6 hours prior to treatment
* Ability to understand and complete pain assessment scales
* Willingness to provide written informed consent

Exclusion Criteria:

* Age below 18 years or above 60 years
* Pregnancy
* Known allergy to local anesthetic agents
* Diagnosis of diabetes mellitus
* Presence of hypothyroidism
* Diagnosis of adrenal insufficiency
* Presence of Raynaud disease
* Uncontrolled diabetes (HbA1c \>7%)
* Presence of periapical pathology detected radiographically
* Presence of sinus tract
* Presence of intraoral or extraoral swelling
* Teeth diagnosed with necrotic pulp
* Presence of referred pain from another tooth or anatomical structure

Where it's running

• Ondokuz Mayıs University
  Samsun, Atakum, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Cangül Keskin, PhD DDS
• Email: cangul.keskin@omu.edu.tr
• Phone: 0905414203909

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pain relief after a single-visit root canal: comparing acetaminophen, NSAIDs, and trypsin-chymotrypsin combo

  This trial tests whether acetaminophen alone, an NSAID, or a combination of trypsin-chymotrypsin with acetaminophen best relieves pain after a single-visit root canal in adults with symptomatic irreversible pulpitis.

  Recruiting Early Phase 1 Dow University of Health Sciences · Karachi, Sindh · NCT07759349

• Partial pulpotomy in mature lower molars with SIP using calcium hypochlorite vs sodium hypochlorite

  This trial tests whether washing the exposed pulp with calcium hypochlorite or with sodium hypochlorite during partial pulpotomy in adults helps healing and reduces pain.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07748676

• Local dexamethasone to improve anesthesia in painful irreversible pulpitis

  This trial tests whether giving dexamethasone under the gum or between tooth-supporting ligaments helps make anesthetic blocks work better and reduce pain in adults with painful irreversible pulpitis in the lower molars.

  Recruiting Marmara University · Istanbul · NCT07672873

• Comparing MTA versus Biodentine for complete pulpotomy in painful molars

  This will test whether MTA or Biodentine works better to relieve pain and preserve the tooth in adults (18–40) with symptomatic irreversible pulpitis in a molar.

  Recruiting at 2 sites Dow University of Health Sciences · Karachi, Sindh and 1 other locations · NCT07483788

• Intraligamentary injection versus inferior alveolar nerve block for painful lower molar pulpitis

  This trial will see if an intraligamentary injection or an inferior alveolar nerve block gives better pain control for adults having root canal treatment of a painful lower molar with symptomatic irreversible pulpitis.

  Recruiting at 2 sites Aula Dental Avanzada · Ferrol, A coruña and 1 other locations · NCT07130760

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.