Cohort study on newly diagnosed COPD in smokers
Official title: Incident Chronic Obstructive pulmoNary dIsease Cohort Study (ICONIC)
Run by Assistance Publique - Hôpitaux de Paris · NCT04252781 · Data updated 2026-11-12
This study is testing how well screening smokers for COPD in regular doctor visits can help identify new patients and track their health over time.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 35 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Créteil, Île-de-France Region) |
| Status | Recruiting |
| Started | August 20, 2020 |
| Main results expected | January 7, 2025 |
| Study ends | February 20, 2026 |
| Registry record updated | January 9, 2025 |
| Trial ID | NCT04252781 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are smokers over the age of 35 with a significant smoking history who are actively smoking.
✕Probably not a fit
Patients with known COPD or those undergoing treatment for cancer may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to systematically screen smokers for Chronic Obstructive Pulmonary Disease (COPD) using spirometry in general medicine settings. It will include 1500 smokers, with the goal of identifying 300 newly diagnosed COPD patients, equally divided by gender. The study will explore the evolution of these patients' conditions based on their initial phenotype and management strategies. By documenting the trajectories of these patients, the study seeks to provide valuable insights into the real-life management of COPD.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of COPD in smokers, potentially reducing healthcare costs and improving patient outcomes.
How similar studies have gone: Other studies have shown success with systematic screening approaches for COPD, indicating potential for this study's methodology.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Inclusion criteria of smokers with spirometry (pre-inclusion) * Age\> 35 years * Smoking \> 20 PA * Active smoking (cessation \< 1 month) * Signature of consent to participate in Phase I of the study Inclusion criteria for patients with incidental COPD * FEV1 / FVC \<70% of the theoretical value and / or \<LLN (Lower limit of normal) * Signature of consent to participate in Phase II of the study Exclusion Criteria: * Known COPD * Cancer being treated * No affiliation to the social security or other social protection scheme * Pregnant or lactating woman * Patient deprived of liberty or under legal protection (under tutorship or curatorship
Where it's running
-
Hopital Henri MONDOR
Créteil, Île-de-France Region, France Recruiting
Study contacts
- Principal investigator: Laurent BOYER, MD — Assistance Publique Hôpitaux de Paris (AP-HP)
- Study coordinator: Laurent BOYER, MD
- Email: laurent.boyer@aphp.fr
- Phone: (0) 1 49 81 26 90
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.