Oliceridine vs Sufentanil for postoperative nausea after CPA surgery
Official title: Comparative Study of Oliceridine Versus Sufentanil for Patient-Controlled Intravenous Analgesia in Improving Postoperative Nausea in Patients Undergoing Cerebellopontine Angle Region Surgery.
Run by Xuanwu Hospital, Beijing · NCT07479446 · Data updated 2026-11-12
This trial tests whether using oliceridine for patient-controlled IV pain relief reduces nausea after cerebellopontine angle surgery compared with sufentanil.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 174 (estimated) |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing) |
| Status | Recruiting |
| Started | March 25, 2026 |
| Main results expected | August 31, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | May 22, 2026 |
| Trial ID | NCT07479446 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18-65 undergoing elective CPA region surgery with planned PCIA and no history of opioid tolerance or prohibitive comorbidities.
✕Probably not a fit
Patients with conditions that predispose to poor response or tolerability to either drug may not experience reduced nausea.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center, double-blind, randomized study compares two opioid options for patient-controlled IV analgesia in adults undergoing CPA region surgery. It aims to see if oliceridine lowers the rate of postoperative nausea within 6-48 hours compared with sufentanil, while also examining pain control. About 174 participants are planned, with primary and several secondary outcomes including pain scores, vomiting, time to first flatus/defecation, and gastrointestinal function scores. The trial will enroll adults aged 18-65 with ASA I-III, and excludes those with opioid tolerance or major comorbidities. Lead sponsor is Xuanwu Hospital, Capital Medical University, Beijing.
Why it matters
Potential benefit: If successful, patients may experience less postoperative nausea and similar or better pain control with oliceridine for PCIA after CPA surgery.
How similar studies have gone: Previous studies in opioid choices for PCIA have shown mixed results; this study adds data specifically for CPA surgery.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Scheduled for elective CPA region surgery with planned PCIA. * Age 18-65 years. * ASA physical status I-III. * Provides written informed consent. Exclusion Criteria: * Opioid tolerance (taking opioids ≥1 week, equivalent to oral morphine ≥50 mg/day or oxycodone ≥30 mg/day). * Severe cardiopulmonary, hepatic, renal, vascular, neurological, hematological, gastrointestinal, or endocrine diseases. * Postoperative ICU admission with tracheal intubation. * BMI ≤18.5 or ≥30 kg/m². * Participation in another clinical trial within 3 months prior to screening.
Where it's running
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Xuanwu Hospital, Capital Medical University
Beijing, China Recruiting
Study contacts
- Study coordinator: Wei Xiao, Dr.
- Email: kitten15@126.com
- Phone: +86-13810971299
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.