Lidocaine via a feeding tube to prevent nausea after bariatric surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18-65 undergoing primary laparoscopic sleeve gastrectomy are randomly assigned to receive either 0.5% lidocaine (20 ml) or normal saline (20 ml) through an orogastric tube after surgery and before extubation. The gastric tube is clamped for 5 minutes to allow mucosal exposure, and patients receive standardized anesthesia and perioperative care. PONV will be tracked in the post-anesthesia care unit and for the first 24 hours postoperatively to determine if lidocaine lowers incidence. The study builds on evidence of lidocaine’s anti-inflammatory and analgesic effects that may influence GI function and vomiting pathways. Overall, the trial examines a simple, inexpensive intervention to reduce a common bariatric complication.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged between 18 and 65 years old;
* American Society of Anesthesiologists (ASA) physical status classification II - III;
* Planned to undergo primary elective laparoscopic sleeve gastrectomy with general anesthesia;
* Capable of giving informed consent.

Exclusion Criteria:

* Known allergy, hypersensitivity or contraindication to lidocaine or amide - type local anesthetics;
* Previous significant liver or kidney dysfunction (e.g., ALT/AST \> 3 times the upper limit of normal, GFR \< 30 mL/min);
* History of epilepsy, cardiac conduction abnormalities or previous diagnosis of malignant hyperthermia;
* Pregnancy or lactation;
* Patients who received systemic lidocaine treatment during the operation;
* History of severe postoperative nausea and vomiting (PONV) or motion sickness, requiring multiple prophylactic medications;
* Emergency or revision bariatric surgery.

Where it's running

• General Hospital of Ningxia Medical University
  Yinchuan, Ningxia, China Recruiting

Study contacts

• Study coordinator: Siying He
• Email: 1342850868@qq.com
• Phone: +86 18209610221

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.