Intraoperative 3D Longitude-Latitude-Depth Localization vs CT-Guided Lung Localization for Small Peripheral Nodules

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized-like comparison evaluates two localization methods for small peripheral pulmonary nodules in adults undergoing video-assisted thoracoscopic sublobar resection. The primary aim is to determine if intraoperative longitude-latitude-depth localization is non-inferior to preoperative CT-guided percutaneous localization in achieving accurate nodule localization. Secondary goals include assessing perioperative outcomes such as time to localize, recovery metrics, pain, quality of life, and complication rates. The study uses anatomical landmarks and imaging measurements to estimate nodule position intraoperatively, potentially reducing preoperative procedures and related risks. Eligible participants are adults aged 18–80 with a single peripheral 0.8–2 cm pulmonary nodule suitable for VATS sublobar resection, with no contraindications to localization or surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinically diagnosed pulmonary nodule by non-contrast chest CT.
* Age 18 to 80 years.
* Expected survival time of at least 12 months.
* Single peripheral pulmonary nodule with a diameter between 0.8 cm and 2 cm.
* Chest CT characteristics meeting both of the following criteria:

  1. Solid component proportion ≤50%.
  2. Located subpleurally or in the outer one-third of the lung parenchyma.
* Willing to undergo VATS-assisted sublobar resection.
* No contraindications to pulmonary localization procedures or surgery.
* Able to understand the study and willing to sign written informed consent.

Exclusion Criteria:

* Use of other localization methods or other surgical procedures.
* Concurrent participation in another clinical study.
* Pregnancy.
* Unwillingness or inability to cooperate with participation in this study for any reason.

Where it's running

• Xingyi People's Hospital
  Xingyi, Guizhou, China Recruiting
• Ningxia Hui Autonomous Region People's Hospital
  Yinchuan, Ningxia, China Recruiting
• Qilu Hospital of Shandong University
  Jinan, Shandong, China Recruiting
• Linqing People's Hospital
  Linqing, Shandong, China Recruiting

Study contacts

• Study coordinator: Zhenguo Sun, Doctor of Medicine (MD)
• Email: sunzg@sdu.edu.cn
• Phone: +86-185-6008-9136

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.