NDT vs. Mirror Therapy for lower limb recovery after sub-acute stroke
Official title: Effects of Neurodevelopmental Technique Versus Mirror Therapy on Coordination, Functions and Ambulation in Sub-acute Hemiplegic Stroke Patients
Run by University of Lahore · NCT07742020 · Data updated 2026-11-12
This trial tests whether neurodevelopmental technique (NDT) or mirror therapy (MT) helps improve leg coordination and walking in people 45–65 with sub-acute stroke.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 45 Years to 65 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University of Lahore Academic / other |
| Locations | 1 site (Lahore, Punjab Province) |
| Status | Recruiting |
| Started | September 8, 2025 |
| Main results expected | July 30, 2026 |
| Study ends | August 15, 2026 |
| Registry record updated | August 3, 2026 |
| Trial ID | NCT07742020 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 45–65 with sub-acute hemiplegic stroke (ischemic or hemorrhagic), clinically stable, oriented, MMSE > 23, and capable of participating in rehabilitation.
✕Probably not a fit
Individuals with recurrent stroke, major systemic illnesses limiting activity, other neurological conditions, or significant visual/hearing impairments may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares two rehabilitation approaches for the lower limb after sub-acute stroke: Neurodevelopmental Technique (NDT) and Mirror Therapy (MT). Forty participants will be enrolled and randomized 1:1 to receive one of the two therapies at the University of Lahore Teaching Hospital. The study aims to determine which method, or whether both, better improves motor coordination, functional movement, and ambulation. Eligibility includes adults 45–65 with sub-acute hemiplegia from ischemic or hemorrhagic stroke, adequate cognitive function (MMSE > 23), and no major comorbidities that limit function. The trial emphasizes practical, manual or visual-feedback-based interventions delivered by clinicians and will assess outcomes related to motor performance and independence in daily activities.
Why it matters
Potential benefit: If successful, the findings could guide clinicians on which rehabilitation approach better supports leg function and walking after sub-acute stroke.
How similar studies have gone: Previous work has shown functional gains with both NDT and MT in stroke rehab, but direct head-to-head comparison for lower-limb outcomes is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Age range between 45 to 65 years * Both genders * Sub-acute stroke hemiplegic cases; clinically stable, fully oriented and conscious. * Both ischemic and hemorrhagic patients were be included. * Patients with mini mental status examination (MMSE) (score \> 23) Exclusion Criteria: * Patients had recurrent stroke. * Any systemic conditions that limit functions such as; cardiac diseases (exertional dyspnea, angina, Myocardial Infarction, Pacemaker) Pulmonary diseases (Asthma, Pulmonary Fibrosis etc.), Diabatic neuropathy, Diabetic foot, Varicose veins etc * Other neurological conditions, such as; foot drop, muscular dystrophy, Myasthenia Gravis, Parkinsonism * Any visual and hearing problem * Any surgical and traumatic history of fractures, dislocations and/or brain injury due to any traumatic events.
Where it's running
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University of Lahore teaching hospital
Lahore, Punjab Province, Pakistan Recruiting
Study contacts
- Principal investigator: Iqra Abdul Jabbar, MSPTN — Faculty of Allied Health Sciences, University Institute of Physical Therapy, University of Lahore
- Study coordinator: Ishaq Ahmed, PHD Ishaq Ahmed, PHD, PHD
- Email: ishaq.ahmed@uipt.uol.edu.pk
- Phone: Telephone: 0334 4066 463
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.