Home-based vs. in-clinic upper extremity rehabilitation after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, parallel-group trial compares tele-CPASS delivered at home to in-person CPASS therapy for adults with recent stroke and persistent upper-extremity impairment. Both groups receive the same 20 hours of task-specific therapy focused on meaningful daily activities, with assessments before, immediately after, and at 6 and 12 months to gauge motor recovery, real-world arm use, and participation. The study builds on prior CPASS work showing benefits of intensive upper-extremity training and explores whether a telerehabilitation format can maintain efficacy while improving access. Eligible participants are adults 21 or older with a recent ischemic or hemorrhagic stroke within 40 days, measurable upper-extremity impairment, and adequate cognitive function to participate. The trial will be conducted at multiple sites in El Paso, TX, led by the University of Texas, El Paso, with collaborators at Texas Tech University Health Sciences Center El Paso and The Catholic University of America.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 21 years or older
* Neuroimaging-confirmed stroke within 40 days prior to enrollment
* Persistent hemiparesis resulting in impaired upper extremity function, defined by a score of 0 to 3 on the NIH Stroke Scale motor arm item
* Able to participate in all study-related activities, including 1-year follow-up
* Short Blessed Memory Orientation and Concentration Scale score less than 8
* Able to follow 2-step commands
* Montreal Cognitive Assessment (MoCA) score greater than 25
* No upper extremity injury or condition that limited upper extremity use prior to the stroke

Exclusion Criteria:

* Inability to provide informed consent
* Persistent disabling neurologic condition, such as multiple sclerosis, Parkinsonism, amyotrophic lateral sclerosis, or dementia requiring medication
* Clinically significant fluctuations in mental status within 72 hours prior to randomization
* Active psychosis, psychosis within the prior 2 years, active substance abuse, or prior substance abuse
* Dense sensory loss, defined by a score of 3 or 4 on the NIH Stroke Scale sensory item
* Ataxia out of proportion to weakness in the affected arm, defined by a score greater than 1 on the NIH Stroke Scale ataxia item
* Not expected to survive 12 months because of other illnesses
* Pregnancy
* Severe aphasia
* Receipt of botulinum toxin or expectation of receiving botulinum toxin during the study period

Where it's running

• Rehabilitation Sciences Complex, University of Texas at El Paso, 3333 N Mesa St, El Paso, TX 79902
  El Paso, Texas, United States Recruiting
• Texas Tech University Health Sciences Center El Paso - Neurology Clinic
  El Paso, Texas, United States Recruiting
• University Medical Center of El Paso - Rehabilitation Services
  El Paso, Texas, United States Recruiting

Study contacts

• Principal investigator: Dr. Shashwati Geed, PT, PhD — Department of Physical Therapy and Movement Sciences, University of Texas at El Paso
• Study coordinator: Dr. Shashwati Geed, PT, PhD
• Email: sgeed@utep.edu
• Phone: 915-747-7289

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Quadriceps muscle activity and gait in people after stroke with stiff-knee gait vs healthy controls

  We will test whether quadriceps muscle activity and walking movement differ between adults with post-stroke stiff-knee gait and healthy adults.

  Recruiting Centre National de Rééducation Fonctionnelle et de Réadaptation · Luxembourg, Luxembourg · NCT07857967

• Balance and fall risk after stroke: Sensorimotor training versus whole-body vibration

  A randomized study tests whether lower-limb sensorimotor training or whole-body vibration can improve balance and reduce fear of falling for people who have had a stroke.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07642154

• Repetitive transcranial magnetic stimulation to improve heart-autonomic function after stroke

  This test adds rTMS to usual neurological rehabilitation to see if it improves heart rate variability, autonomic symptoms, arm strength, and quality of life in people at least three months after a stroke.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar · NCT07482501

• Spatial StimelMD for upper-limb recovery after stroke or traumatic brain injury

  This trial will test whether adding the Spatial StimelMD device to standard rehabilitation helps adults with upper-limb weakness after stroke or traumatic brain injury improve arm movement.

  Recruiting Motion Informatics LTD · Haifa · NCT07404761

• Optimizing low-intensity focused ultrasound to improve arm movement after stroke

  This research will try low-intensity focused ultrasound on the motor cortex to see if different power levels and timing improve arm strength and motor learning in people at least six months after a first stroke.

  Recruiting Duke University · Durham, North Carolina · NCT07220005

• Deep phenotyping to explore recovery in young adults after stroke

  This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

  Recruiting The Florey Institute of Neuroscience and Mental Health · Heidelberg, Victoria and 1 other locations · NCT07019493

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.