Effects of Potassium on Blood Vessel Health in Older Adults With High Salt Intake

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy adults aged 55-75, all postmenopausal women and men, will try three fixed-diet phases each lasting 10 days, with at least a two-week washout between phases. The diets vary in sodium (low vs high) and potassium (low vs high) content, and all meals are provided. Endothelial function and other cardiovascular measures will be assessed at the end of each diet to see if potassium modifies the effects of sodium. The order of diets is randomized to minimize bias. The study aims to understand sex differences in endothelial responses to sodium and potassium in older adults without cardiometabolic disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ages 55-75 years
* At least one-year post-menopause (females)
* Willing and able to attend laboratory visits

Exclusion Criteria:

* BMI ≥35 kg/m2
* Seated blood pressure \>135/85 mmHg
* Current diagnosis or history of cardiovascular disease, diabetes, renal disease, cancer, or major cardiovascular event (e.g. heart attack or stroke)
* Taking exogenous hormones or hormone replacement therapy
* Following a vegan or gluten free diet
* Significant weight loss (\>10% of body weight) in the last 6 months, or actively trying to lose weight
* Current or recent use of a diuretic (within the past 6 months) (e.g. spironolactone, eplerenone)
* Current or recent use of a potassium binding medication (within the past 6 months)
* Current use of blood pressure lowering medications (e.g. ACE inhibitors, calcium channel blockers, diuretics, vasodilators, beta blockers, AngII receptor blockers)
* Current or recent use of the medication trimethoprim
* Elevated blood lipids (LDL cholesterol ≥190 mg/dL)
* Elevated serum potassium level (\>5.1 mmol/L)
* Elevated BUN (\>22 mg/dL)
* Elevated creatinine (\>1.2 mg/dL)
* Low eGFR (\<90 mL/min/1.73 m²)
* Current or recent use of tobacco, nicotine, or illicit drugs
* Radical hysterectomy or oophorectomy (females)

Where it's running

• Florida State University
  Tallahassee, Florida, United States Recruiting

Study contacts

• Principal investigator: Andrea Lobene — Florida State University
• Study coordinator: Andrea Lobene
• Email: alobene@fsu.edu
• Phone: 850-644-1829

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.